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在挪威医疗体系中向聚合酶链反应诊断隐孢子虫病和贾第虫病的转变:报道病例的增加是否是由于检测的灵敏度提高或检测算法的改变?

Transition to PCR diagnosis of cryptosporidiosis and giardiasis in the Norwegian healthcare system: could the increase in reported cases be due to higher sensitivity or a change in the testing algorithm?

机构信息

Parasitology, Department of Paraclinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, NMBU Veterinærhøgskolen, Postboks 5003, 1432, Ås, Norway.

Tallaght University Hospital, Dublin, Ireland.

出版信息

Eur J Clin Microbiol Infect Dis. 2022 May;41(5):835-839. doi: 10.1007/s10096-022-04426-3. Epub 2022 Mar 4.

DOI:10.1007/s10096-022-04426-3
PMID:35243573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8893977/
Abstract

Cryptosporidiosis has been a notifiable infection in Norway since 2012 and giardiasis since 1977. For both infections, there has been an increase in notified cases. We used a questionnaire to explore whether this may be associated with implementation of molecular diagnostic methods. We received responses from 14 of 16 laboratories, most of which had implemented molecular diagnostic methods for these parasites. Algorithms for testing had also been modified, and several laboratories now test more faecal samples than previously for both parasites. The increase in reported cases may reflect not only higher sensitivity of diagnostic methods, but also more sample testing.

摘要

隐孢子虫病自 2012 年起在挪威被列为法定传染病,贾第虫病自 1977 年起也是如此。这两种感染的报告病例都有所增加。我们使用问卷来探讨这是否与分子诊断方法的实施有关。我们收到了 16 个实验室中的 14 个的回复,其中大多数已经为这些寄生虫实施了分子诊断方法。检测算法也进行了修改,现在有几个实验室对这两种寄生虫的粪便样本检测量比以前都有所增加。报告病例的增加不仅可能反映了诊断方法的灵敏度提高,还可能反映了更多的样本检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d496/9033733/e2792d0adc3e/10096_2022_4426_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d496/9033733/bdc2769b8579/10096_2022_4426_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d496/9033733/e2792d0adc3e/10096_2022_4426_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d496/9033733/bdc2769b8579/10096_2022_4426_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d496/9033733/e2792d0adc3e/10096_2022_4426_Fig2_HTML.jpg

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