Unidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Laboratorio 5, primer piso, Unidad Multidisciplinaria de Investigación Experimental (UMIEZ-Z), Facultad de Estudios Superiores-Zaragoza, Campus II, UNAM, Mexico City, Mexico.
Environ Toxicol. 2022 Jul;37(7):1587-1596. doi: 10.1002/tox.23508. Epub 2022 Mar 3.
Vanadium(V) and vanadium(IV) are the predominant redox forms present in the environment, and epidemiological studies have reported that prenatal vanadium exposure is associated with restricted fetal growth and adverse birth outcomes. However, data about the toxic effects of vanadium(IV) oxide (V O ) on the development of mammals are still limited. Therefore, in this work, 4.7, 9.4, or 18.7 mg/kg body weight/injection/day V O was administered through an intraperitoneal (ip) injection to pregnant mice from gestational days 6 to 16. The results showed that V O produced maternal and embryo-fetal toxicity and external abnormalities in the offspring, such as malrotated and malpositioned hind limbs, hematomas and head injuries. Moreover, the skeletons of the fetuses presented reduced ossification of the cranial bones, including the frontal and parietal bones, corresponding to head injuries observed in the external assessment of the fetuses. These results demonstrate that administration of V O to pregnant females in the organogenesis period adversely affects embryonic development.
钒(V)和钒(IV)是环境中主要的氧化还原形式，流行病学研究报告称，产前钒暴露与胎儿生长受限和不良出生结局有关。然而，关于四氧化二钒 (V O ) 对哺乳动物发育的毒性作用的数据仍然有限。因此，在这项工作中，通过腹腔内 (ip) 注射向怀孕 6 至 16 天的小鼠给予 4.7、9.4 或 18.7mg/kg 体重/天的 V O 。结果表明，V O 产生了母体和胚胎胎儿毒性，并导致后代出现外部异常，如后腿旋转和错位、血肿和头部损伤。此外，胎儿骨骼的颅骨骨化减少，包括额骨和顶骨，与在胎儿外部评估中观察到的头部损伤相对应。这些结果表明，在器官发生期向怀孕雌性动物给予 V O 会对胚胎发育产生不利影响。
