Tunis Med. 2021;99(5):560-568.
Lung cancer is the leading cause of cancer mortality worldwide. Even after radical resection, the rate of recurrence of non-small cell lung cancer remains high.
To identify the profile of patients operated for lung cancer and to study the prognostic factors of tumor recurrence.
We performed a retrospective study including 67 cases of lung cancer with curative surgery, hospitalized between 2010 and 2016.
The mean age was 61 years. The sex ratio was 21. The average time to diagnosis was 22 days. The average time to start treatment was 10 days. The most common histological type was adenocarcinoma (63%). Lobectomy was performed in 63% of the patients. Tumor recurrence was noted in 40% of the patients. The average time between recurrence and the surgical treatment was 12 months. The most common location of recurrence was the lung (70%). Recurrence was more common among adenocarcinoma and smokers older than 60 years. The majority of locally advanced and metastatic cancers have recurred. The average survival was 56 ± 4months. Better survival rates were observed in young patients, with less than 25 pack-years of early-stage, no lymph node involvement, and patients who received adjuvant chemotherapy. The probability of survival was 5 years for all tumor stages.
The prognostic factors for recurrence after radical resection for lung cancer were: the age of patients, smoking history, histological type, tumor stage, and surgical procedure.
肺癌是全球癌症死亡的主要原因。即使进行根治性切除，非小细胞肺癌的复发率仍然很高。
确定接受肺癌手术治疗患者的特征，并研究肿瘤复发的预后因素。
我们进行了一项回顾性研究，纳入了 2010 年至 2016 年间接受根治性手术治疗的 67 例肺癌患者。
平均年龄为 61 岁，男女比例为 21。平均诊断时间为 22 天，平均开始治疗时间为 10 天。最常见的组织学类型是腺癌（63%）。63%的患者接受了肺叶切除术。40%的患者出现肿瘤复发。复发与手术治疗之间的平均时间为 12 个月。最常见的复发部位是肺部（70%）。腺癌和 60 岁以上的吸烟者更易复发。大多数局部晚期和转移性癌症已经复发。平均生存时间为 56±4 个月。年轻患者、早期 25 包年以下吸烟史、无淋巴结受累以及接受辅助化疗的患者生存率更好。所有肿瘤分期的 5 年生存率为 50%。
根治性切除术后肺癌复发的预后因素包括：患者年龄、吸烟史、组织学类型、肿瘤分期和手术方式。
