Boland Mary Regina, Shahn Zachary, Madigan David, Hripcsak George, Tatonetti Nicholas P
Department of Biomedical Informatics Observational Health Data Sciences and Informatics (OHDSI).
Department of Statistics.
J Am Med Inform Assoc. 2015 Sep;22(5):1042-53. doi: 10.1093/jamia/ocv046. Epub 2015 Jun 2.
An individual's birth month has a significant impact on the diseases they develop during their lifetime. Previous studies reveal relationships between birth month and several diseases including atherothrombosis, asthma, attention deficit hyperactivity disorder, and myopia, leaving most diseases completely unexplored. This retrospective population study systematically explores the relationship between seasonal affects at birth and lifetime disease risk for 1688 conditions.
We developed a hypothesis-free method that minimizes publication and disease selection biases by systematically investigating disease-birth month patterns across all conditions. Our dataset includes 1 749 400 individuals with records at New York-Presbyterian/Columbia University Medical Center born between 1900 and 2000 inclusive. We modeled associations between birth month and 1688 diseases using logistic regression. Significance was tested using a chi-squared test with multiplicity correction.
We found 55 diseases that were significantly dependent on birth month. Of these 19 were previously reported in the literature (P < .001), 20 were for conditions with close relationships to those reported, and 16 were previously unreported. We found distinct incidence patterns across disease categories.
Lifetime disease risk is affected by birth month. Seasonally dependent early developmental mechanisms may play a role in increasing lifetime risk of disease.
一个人的出生月份对其一生中所患疾病有重大影响。先前的研究揭示了出生月份与包括动脉粥样硬化血栓形成、哮喘、注意力缺陷多动障碍和近视在内的多种疾病之间的关系，而大多数疾病则完全未被探索。这项回顾性人群研究系统地探讨了出生时的季节影响与1688种疾病的终生患病风险之间的关系。
我们开发了一种无假设方法，通过系统地研究所有疾病的疾病-出生月份模式，将发表偏倚和疾病选择偏倚降至最低。我们的数据集包括1749400名在纽约长老会/哥伦比亚大学医学中心有记录的个体，他们出生于1900年至2000年（含）之间。我们使用逻辑回归对出生月份与1688种疾病之间的关联进行建模。使用带有多重校正的卡方检验来检验显著性。
我们发现55种疾病与出生月份显著相关。其中19种先前已在文献中报道（P <.001），20种与已报道疾病关系密切，16种先前未被报道。我们发现不同疾病类别的发病率模式各不相同。
终生患病风险受出生月份影响。季节性依赖的早期发育机制可能在增加终生患病风险中起作用。
