Department of Clinical Epidemiology, University of the Philippines, Manila, Philippines
Department of Pediatrics, Batangas Medical Center, Batangas, Philippines.
BMJ Case Rep. 2022 Mar 4;15(3):e242843. doi: 10.1136/bcr-2021-242843.
Acute leukaemia is the most common childhood cancer. The clinical presentation of acute leukaemia includes fever, pallor, bleeding tendencies, hepatosplenomegaly, lymphadenopathy and bone pains. This case is about a 7-year-old boy who presented with 2 months of progressive low back pain after jumping into the sea. Radiologic workup showed compression fractures in the T6-L5 regions of the spine. Trauma and osteogenesis imperfecta were considered initially until the patient developed the classic features of leukaemia. Analysis of the bone marrow aspirate, 2 months after the sea incident, revealed B cell acute lymphoblastic leukaemia (ALL). The low back pain subsided after a week of chemotherapy. A symptom that involves bone pain in a child needs thorough evaluation because a delay in diagnosis affects the outcome of treatment. ALL has been lingering at the time of his accident and this has caused weakening of his spine that resulted in much more severe injury than would have occurred in the absence of the ALL.
急性白血病是最常见的儿童癌症。急性白血病的临床表现包括发热、苍白、出血倾向、肝脾肿大、淋巴结病和骨痛。本病例为 7 岁男孩,在跳入海中后 2 个月出现进行性腰痛。影像学检查显示 T6-L5 脊柱区域的压缩性骨折。最初考虑了创伤和成骨不全症,直到患者出现白血病的典型特征。在海难发生后 2 个月对骨髓抽吸物进行分析,显示 B 细胞急性淋巴细胞白血病(ALL)。化疗一周后,腰痛缓解。涉及儿童骨痛的症状需要进行彻底评估,因为诊断延迟会影响治疗效果。ALL 在他发生事故时一直存在,这导致他的脊柱变弱,导致比没有 ALL 时更严重的损伤。