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Within-host models of SARS-CoV-2: What can it teach us on the biological factors driving virus pathogenesis and transmission?

作者信息

Prague Mélanie, Alexandre Marie, Thiébaut Rodolphe, Guedj Jérémie

机构信息

Univ. Bordeaux, Department of Public Health, INSERM UMR 1219 Bordeaux Population Health Research Centre, Inria SISTM, Bordeaux, France; Vaccine Research Institute, Créteil, France.

Univ. Bordeaux, Department of Public Health, INSERM UMR 1219 Bordeaux Population Health Research Centre, Inria SISTM, Bordeaux, France; Vaccine Research Institute, Créteil, France.

出版信息

Anaesth Crit Care Pain Med. 2022 Apr;41(2):101055. doi: 10.1016/j.accpm.2022.101055. Epub 2022 Mar 2.

DOI:10.1016/j.accpm.2022.101055
PMID:35247638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8889677/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590b/8889677/b242fba29090/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590b/8889677/b242fba29090/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590b/8889677/b242fba29090/gr1_lrg.jpg

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Elife. 2022 Jul 8;11:e75427. doi: 10.7554/eLife.75427.
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Viral Dynamics of SARS-CoV-2 Variants in Vaccinated and Unvaccinated Persons.接种疫苗和未接种疫苗人群中新冠病毒变异株的病毒动力学
N Engl J Med. 2021 Dec 23;385(26):2489-2491. doi: 10.1056/NEJMc2102507. Epub 2021 Dec 1.
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In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness.
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The race to understand immunopathology in COVID-19: Perspectives on the impact of quantitative approaches to understand within-host interactions.新冠病毒免疫病理学的探索之旅:关于定量方法在理解宿主内相互作用方面影响的观点
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Modeling recapitulates the heterogeneous outcomes of SARS-CoV-2 infection and quantifies the differences in the innate immune and CD8 T-cell responses between patients experiencing mild and severe symptoms.建模再现了 SARS-CoV-2 感染的异质结果,并量化了轻症和重症患者之间固有免疫和 CD8 T 细胞反应的差异。
PLoS Pathog. 2022 Jun 27;18(6):e1010630. doi: 10.1371/journal.ppat.1010630. eCollection 2022 Jun.
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Nat Med. 2021 Nov;27(11):2032-2040. doi: 10.1038/s41591-021-01540-1. Epub 2021 Sep 29.
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Elife. 2021 Sep 27;10:e69302. doi: 10.7554/eLife.69302.
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