天然化合物作为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）内吞作用的抑制剂：一种对抗2019冠状病毒病（COVID-19）的有前景的方法。
Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19.
作者信息
Kiani Aysha Karim, Dhuli Kristjana, Anpilogov Kyrylo, Bressan Simone, Dautaj Astrit, Dundar Munis, Beccari Tommaso, Ergoren Mahmut C, Bertelli Matteo
机构信息
MAGI EUREGIO, Bolzano, Italy.
EBTNA-LAB, Rovereto (TN), Italy.
出版信息
Acta Biomed. 2020 Nov 9;91(13-S):e2020008. doi: 10.23750/abm.v91i13-S.10520.
Abstract
BACKGROUND AND AIM
The recent COVID-19 pandemic caused by SARS-CoV-2 affected more than six million people and caused thousands of deaths. The lack of effective drugs or vaccines against SARS-CoV-2 further worsened the situation. This review is focused on the identification of molecules that may inhibit viral entry into host cells by endocytosis.
METHODS
We performed the literature search for these natural compounds in the articles indexed in PubMed.
RESULTS
Natural products against viral infections have been gaining importance in recent years. Specific natural compounds like phytosterols, polyphenols, flavonoids, citrus, galangal, curcuma and hydroxytyrosol are being analyzed to understand whether they could inhibit SARS-CoV-2.
CONCLUSIONS
We reviewed natural compounds with potential antiviral activity against SARS-CoV-2 that could be used as a treatment for COVID-19.
摘要
背景与目的
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发的近期新型冠状病毒肺炎疫情感染了超过600万人，并导致数千人死亡。缺乏针对SARS-CoV-2的有效药物或疫苗使情况进一步恶化。本综述聚焦于鉴定可能通过内吞作用抑制病毒进入宿主细胞的分子。
方法
我们在PubMed索引的文章中对这些天然化合物进行了文献检索。
结果
近年来，天然产物在对抗病毒感染方面变得愈发重要。目前正在分析特定的天然化合物，如植物甾醇、多酚、黄酮类化合物、柑橘、高良姜、姜黄和羟基酪醇，以了解它们是否能够抑制SARS-CoV-2。
结论
我们综述了具有抗SARS-CoV-2潜在抗病毒活性的天然化合物，这些化合物可用于治疗新型冠状病毒肺炎。
相似文献
1
Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19.天然化合物作为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）内吞作用的抑制剂：一种对抗2019冠状病毒病（COVID-19）的有前景的方法。
Acta Biomed. 2020 Nov 9;91(13-S):e2020008. doi: 10.23750/abm.v91i13-S.10520.
2
[Repurposing of chlorpromazine in COVID-19 treatment: the reCoVery study].[氯丙嗪在新冠病毒肺炎治疗中的重新应用：恢复研究]
Encephale. 2020 Jun;46(3S):S35-S39. doi: 10.1016/j.encep.2020.04.010. Epub 2020 Apr 29.
3
A pilot study on the preventative potential of alpha-cyclodextrin and hydroxytyrosol against SARS-CoV-2 transmission.一项关于α-环糊精和羟基酪醇对新型冠状病毒传播预防潜力的初步研究。
Acta Biomed. 2020 Nov 9;91(13-S):e2020022. doi: 10.23750/abm.v91i13-S.10817.
4
Pilot study for the evaluation of safety profile of a potential inhibitor of SARS-CoV-2 endocytosis.一项评估新型冠状病毒内吞作用潜在抑制剂安全性的初步研究。
Acta Biomed. 2020 Nov 9;91(13-S):e2020009. doi: 10.23750/abm.v91i13-S.10583.
5
Emergence, Transmission, and Potential Therapeutic Targets for the COVID-19 Pandemic Associated with the SARS-CoV-2.与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）相关的2019冠状病毒病大流行的出现、传播及潜在治疗靶点
Cell Physiol Biochem. 2020 Aug 25;54(4):767-790. doi: 10.33594/000000254.
6
Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2.天然类黄酮作为潜在的血管紧张素转换酶 2 抑制剂用于抗 SARS-CoV-2。
Molecules. 2020 Sep 1;25(17):3980. doi: 10.3390/molecules25173980.
7
Investigating hypothiocyanite against SARS-CoV-2.研究次硫氰酸盐对新型冠状病毒的作用。
Int J Hyg Environ Health. 2020 Jun;227:113520. doi: 10.1016/j.ijheh.2020.113520. Epub 2020 Apr 6.
8
Drug repositioning is an alternative for the treatment of coronavirus COVID-19.药物重定位是治疗冠状病毒 COVID-19 的一种替代方法。
Int J Antimicrob Agents. 2020 Jun;55(6):105969. doi: 10.1016/j.ijantimicag.2020.105969. Epub 2020 Apr 9.
9
Approaching coronavirus disease 2019: Mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2.探讨 2019 年冠状病毒病：具有抗 SARS-CoV-2 潜在活性的已上市药物的作用机制。
Biochem Pharmacol. 2020 Oct;180:114169. doi: 10.1016/j.bcp.2020.114169. Epub 2020 Jul 23.
10
COVID-19: Underpinning Research for Detection, Therapeutics, and Vaccines Development.新冠病毒：检测、治疗与疫苗研发的基础研究
Pharm Nanotechnol. 2020;8(4):323-353. doi: 10.2174/2211738508999200817163335.
引用本文的文献
1
Therapeutic Potential of Propolis and Royal Jelly in Encephalitozoon Intestinalis Infection: An in Vitro Study.蜂胶和蜂王浆对肠道脑胞内原虫感染的治疗潜力：一项体外研究
Acta Parasitol. 2025 Jan 24;70(1):26. doi: 10.1007/s11686-024-00956-2.
2
Antibacterial, Antifungal, Antiviral Activity, and Mechanisms of Action of Plant Polyphenols.植物多酚的抗菌、抗真菌、抗病毒活性及作用机制
Microorganisms. 2024 Dec 4;12(12):2502. doi: 10.3390/microorganisms12122502.
3
COVID-19 Complications: Oxidative Stress, Inflammation, and Mitochondrial and Endothelial Dysfunction.COVID-19 并发症：氧化应激、炎症以及线粒体和内皮功能障碍。
Int J Mol Sci. 2023 Oct 4;24(19):14876. doi: 10.3390/ijms241914876.
4
A Review of Classification, Biosynthesis, Biological Activities and Potential Applications of Flavonoids.黄酮类化合物的分类、生物合成、生物活性及潜在应用综述
Molecules. 2023 Jun 25;28(13):4982. doi: 10.3390/molecules28134982.
5
S Protein, ACE2 and Host Cell Proteases in SARS-CoV-2 Cell Entry and Infectivity; Is Soluble ACE2 a Two Blade Sword? A Narrative Review.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）进入细胞及感染性过程中的刺突蛋白（S蛋白）、血管紧张素转换酶2（ACE2）和宿主细胞蛋白酶；可溶性ACE2是双刃剑吗？一篇综述
Vaccines (Basel). 2023 Jan 17;11(2):204. doi: 10.3390/vaccines11020204.
6
Foods of the Mediterranean diet: citrus, cucumber and grape.地中海饮食的食物：柑橘、黄瓜和葡萄。
J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E21-E27. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2743. eCollection 2022 Jun.
7
Dietary supplements for the management of COVID-19 symptoms.用于管理 COVID-19 症状的膳食补充剂。
J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E221-E227. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2764. eCollection 2022 Jun.
8
Insight into the role of clathrin-mediated endocytosis inhibitors in SARS-CoV-2 infection.解析网格蛋白介导的内吞作用抑制剂在 SARS-CoV-2 感染中的作用。
Rev Med Virol. 2023 Jan;33(1):e2403. doi: 10.1002/rmv.2403. Epub 2022 Nov 7.
9
Early Outpatient Treatment of COVID-19: A Retrospective Analysis of 392 Cases in Italy.新冠病毒病的早期门诊治疗：意大利392例病例的回顾性分析
J Clin Med. 2022 Oct 18;11(20):6138. doi: 10.3390/jcm11206138.
10
Screening and evaluation of cytotoxicity and antiviral effects of secondary metabolites from water extracts of Bersama abyssinica against SARS-CoV-2 Delta.筛选和评价埃塞俄比亚血桐水提物次生代谢产物对 SARS-CoV-2 Delta 的细胞毒性和抗病毒作用
BMC Complement Med Ther. 2022 Oct 26;22(1):280. doi: 10.1186/s12906-022-03754-3.
本文引用的文献
1
Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (M) inhibitors to unveil a hope against COVID-19.多维计算机筛选策略鉴定天然多酚类化合物作为 SARS-CoV-2 主蛋白酶（Mpro）抑制剂，以期为抗击 COVID-19 带来新希望。
Comput Biol Med. 2022 Jun;145:105452. doi: 10.1016/j.compbiomed.2022.105452. Epub 2022 Mar 26.
2
COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression.2019冠状病毒病：关于研究β-环糊精与西曲溴铵联合含漱预防感染及病情进展效果的建议
J Clin Med. 2020 Apr 15;9(4):1126. doi: 10.3390/jcm9041126.
3
CD-sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID-19).CD-sACE2 包含物：一种针对 2019 年冠状病毒病（COVID-19）的有效治疗方法。
J Med Virol. 2020 Oct;92(10):1721-1723. doi: 10.1002/jmv.25804. Epub 2020 Apr 17.
4
Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19.靶向内吞途径和自噬过程作为 COVID-19 的一种新治疗策略。
Int J Biol Sci. 2020 Mar 15;16(10):1724-1731. doi: 10.7150/ijbs.45498. eCollection 2020.
5
Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?天然小分子作为冠状病毒脂质依赖性附着宿主细胞的抑制剂：一种降低SARS-CoV-2感染性的可能策略？
Acta Biomed. 2020 Mar 19;91(1):161-164. doi: 10.23750/abm.v91i1.9402.
6
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.全长人血管紧张素转化酶 2 识别 SARS-CoV-2 的结构基础。
Science. 2020 Mar 27;367(6485):1444-1448. doi: 10.1126/science.abb2762. Epub 2020 Mar 4.
7
Flavonoids as Antiviral Agents for ().黄酮类化合物作为抗病毒药物用于（）。
Viruses. 2020 Feb 6;12(2):184. doi: 10.3390/v12020184.
8
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.新冠病毒的基因组特征和流行病学：对病毒起源和受体结合的影响。
Lancet. 2020 Feb 22;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8. Epub 2020 Jan 30.
9
A Novel Coronavirus from Patients with Pneumonia in China, 2019.2019 年中国肺炎患者中的一种新型冠状病毒。
N Engl J Med. 2020 Feb 20;382(8):727-733. doi: 10.1056/NEJMoa2001017. Epub 2020 Jan 24.
10
Coronavirus envelope protein: current knowledge.冠状病毒包膜蛋白：当前的认识。
Virol J. 2019 May 27;16(1):69. doi: 10.1186/s12985-019-1182-0.
Zotero 插件