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Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (M) inhibitors to unveil a hope against COVID-19.多维计算机筛选策略鉴定天然多酚类化合物作为 SARS-CoV-2 主蛋白酶（Mpro）抑制剂，以期为抗击 COVID-19 带来新希望。
Comput Biol Med. 2022 Jun;145:105452. doi: 10.1016/j.compbiomed.2022.105452. Epub 2022 Mar 26.
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COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression.2019冠状病毒病：关于研究β-环糊精与西曲溴铵联合含漱预防感染及病情进展效果的建议
J Clin Med. 2020 Apr 15;9(4):1126. doi: 10.3390/jcm9041126.
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CD-sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID-19).CD-sACE2 包含物：一种针对 2019 年冠状病毒病（COVID-19）的有效治疗方法。
J Med Virol. 2020 Oct;92(10):1721-1723. doi: 10.1002/jmv.25804. Epub 2020 Apr 17.
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Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19.靶向内吞途径和自噬过程作为 COVID-19 的一种新治疗策略。
Int J Biol Sci. 2020 Mar 15;16(10):1724-1731. doi: 10.7150/ijbs.45498. eCollection 2020.
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Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?天然小分子作为冠状病毒脂质依赖性附着宿主细胞的抑制剂：一种降低SARS-CoV-2感染性的可能策略？
Acta Biomed. 2020 Mar 19;91(1):161-164. doi: 10.23750/abm.v91i1.9402.
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Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.全长人血管紧张素转化酶 2 识别 SARS-CoV-2 的结构基础。
Science. 2020 Mar 27;367(6485):1444-1448. doi: 10.1126/science.abb2762. Epub 2020 Mar 4.
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Flavonoids as Antiviral Agents for ().黄酮类化合物作为抗病毒药物用于（）。
Viruses. 2020 Feb 6;12(2):184. doi: 10.3390/v12020184.
8
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.新冠病毒的基因组特征和流行病学：对病毒起源和受体结合的影响。
Lancet. 2020 Feb 22;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8. Epub 2020 Jan 30.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.2019 年中国肺炎患者中的一种新型冠状病毒。
N Engl J Med. 2020 Feb 20;382(8):727-733. doi: 10.1056/NEJMoa2001017. Epub 2020 Jan 24.
10
Coronavirus envelope protein: current knowledge.冠状病毒包膜蛋白：当前的认识。
Virol J. 2019 May 27;16(1):69. doi: 10.1186/s12985-019-1182-0.

天然化合物作为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）内吞作用的抑制剂：一种对抗2019冠状病毒病（COVID-19）的有前景的方法。

Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19.

作者信息

Kiani Aysha Karim, Dhuli Kristjana, Anpilogov Kyrylo, Bressan Simone, Dautaj Astrit, Dundar Munis, Beccari Tommaso, Ergoren Mahmut C, Bertelli Matteo

机构信息

MAGI EUREGIO, Bolzano, Italy.

EBTNA-LAB, Rovereto (TN), Italy.

出版信息

Acta Biomed. 2020 Nov 9;91(13-S):e2020008. doi: 10.23750/abm.v91i13-S.10520.

DOI:10.23750/abm.v91i13-S.10520
PMID:33170174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8023130/
Abstract

BACKGROUND AND AIM

The recent COVID-19 pandemic caused by SARS-CoV-2 affected more than six million people and caused thousands of deaths. The lack of effective drugs or vaccines against SARS-CoV-2 further worsened the situation. This review is focused on the identification of molecules that may inhibit viral entry into host cells by endocytosis.

METHODS

We performed the literature search for these natural compounds in the articles indexed in PubMed.

RESULTS

Natural products against viral infections have been gaining importance in recent years. Specific natural compounds like phytosterols, polyphenols, flavonoids, citrus, galangal, curcuma and hydroxytyrosol are being analyzed to understand whether they could inhibit SARS-CoV-2.

CONCLUSIONS

We reviewed natural compounds with potential antiviral activity against SARS-CoV-2 that could be used as a treatment for COVID-19.

摘要

背景与目的

由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发的近期新型冠状病毒肺炎疫情感染了超过600万人，并导致数千人死亡。缺乏针对SARS-CoV-2的有效药物或疫苗使情况进一步恶化。本综述聚焦于鉴定可能通过内吞作用抑制病毒进入宿主细胞的分子。

方法

我们在PubMed索引的文章中对这些天然化合物进行了文献检索。

结果

近年来，天然产物在对抗病毒感染方面变得愈发重要。目前正在分析特定的天然化合物，如植物甾醇、多酚、黄酮类化合物、柑橘、高良姜、姜黄和羟基酪醇，以了解它们是否能够抑制SARS-CoV-2。

结论

我们综述了具有抗SARS-CoV-2潜在抗病毒活性的天然化合物，这些化合物可用于治疗新型冠状病毒肺炎。