State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China.
State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China.
Environ Res. 2022 Aug;211:113045. doi: 10.1016/j.envres.2022.113045. Epub 2022 Mar 3.
The extensive use of antibiotics leads to the occurrences of antibiotic resistance genes (ARGs) in aquatic environment. As an emerging environmental pollutant, its pollution in aquatic environment has aroused widespread concern. However, the residues of antibiotics and antibiotic resistance genes in drinking water distribution system were barely reported up to now. Here, we studied the correlation and coordination between chlorine resistance mechanism and antibiotic resistance mechanism of chlorine-resistant bacteria. Antibiotics induce the resistance of chlorine-resistant bacteria (CRB) to NaClO, so that low-dose disinfectants can not inactivate CRB. We put forward a strategy to control the growth of CRB by controlling the concentration of biodegradable dissolved organic carbon (BDOC) in the front section of the water network. Moreover, We screened two strains of chlorine-resistant bacteria with different antibiotic resistance after mixed culture, the results showed that antibiotic resistance could spread horizontally among different kinds of bacteria. Then, the non-pathogenic bacteria can be used as a carrier, causing the pathogen to become resistant to antibiotic, and ultimately pose harm to human health. Generally, the antibiotic, antibiotic resistant genes, and the chlorine disinfectants added in water treatment plants will interact with bacteria in the water supply pipe network, which causes pollution to drinking water.
抗生素的广泛使用导致抗生素耐药基因（ARGs）在水环境中出现。作为一种新兴的环境污染物，其在水环境中的污染已引起广泛关注。然而，迄今为止，饮用水分配系统中抗生素和抗生素耐药基因的残留几乎没有报道。在这里，我们研究了耐氯细菌的氯耐药机制和抗生素耐药机制之间的相关性和协调性。抗生素诱导耐氯细菌（CRB）对次氯酸钠的耐药性，从而使低剂量消毒剂不能灭活 CRB。我们提出了一种通过控制水网前段可生物降解溶解有机碳（BDOC）浓度来控制 CRB 生长的策略。此外，我们在混合培养后筛选出两株具有不同抗生素耐药性的耐氯细菌，结果表明抗生素耐药性可以在不同种类的细菌之间水平传播。然后，非致病菌可以作为载体，使致病菌对抗生素产生耐药性，最终对人类健康造成危害。一般来说，抗生素、抗生素耐药基因和水处理厂中添加的氯消毒剂会与供水管网中的细菌相互作用，从而造成饮用水污染。
