Bradley Margaret M, Sambuco Nicola, Lang Peter J
Center for the Study of Emotion and Attention, University of Florida, Gainesville, FL, USA.
Center for the Study of Emotion and Attention, University of Florida, Gainesville, FL, USA.
Neuropsychologia. 2022 May 3;169:108203. doi: 10.1016/j.neuropsychologia.2022.108203. Epub 2022 Mar 4.
Understanding the neural correlates of repetitive retrieval of emotional events is critical in addressing pathological emotional processing, as repeated processing is central for a number of different therapeutic interventions. In the current study, single-trial functional brain activity was assessed in key regions implicated in episodic retrieval, including the medial prefrontal cortex (mPFC), anterior hippocampus, posterior hippocampus, and the posteromedial parietal cortex (i.e., posterior cingulate cortex and the precuneus) following repeated retrieval of pleasant and unpleasant autobiographical events. Replicating previous studies, repetition prompted reduced blood-oxygen-level-dependent (BOLD) amplitude in the anterior hippocampus and the mPFC, but not in the posterior hippocampus, due to no functional activity during mental imagery, or in the posteromedial parietal cortex, due to enhanced activation that was sustained across repetitions. Neural activation during pleasant and unpleasant autobiographical retrieval did not differ as a function of repetition, indicating similar processing effects regardless of motivational relevance. Taken together, the hedonic valence of retrieved memories does not affect functional activity associated with repeated retrieval of episodic events, in which the pattern of BOLD amplitude change suggests a dissociation between the hippocampal-prefrontal circuit, which shows repetition suppression, and the posteromedial parietal cortex, which shows sustained activation.
了解情绪事件重复提取的神经关联对于解决病理性情绪加工至关重要，因为重复加工是许多不同治疗干预的核心。在当前研究中，在重复提取愉快和不愉快的自传体事件后，对参与情景提取的关键区域（包括内侧前额叶皮质（mPFC）、前海马体、后海马体和后内侧顶叶皮质（即后扣带回皮质和楔前叶））的单试次功能脑活动进行了评估。重复先前的研究，由于在心理意象期间没有功能活动，重复导致前海马体和mPFC中血氧水平依赖（BOLD）振幅降低，但后海马体中没有，或者在后内侧顶叶皮质中也没有，因为在重复过程中激活增强且持续。愉快和不愉快的自传体提取过程中的神经激活并未因重复而有所不同，这表明无论动机相关性如何，加工效果相似。综上所述，检索记忆的享乐效价不会影响与情景事件重复检索相关的功能活动，其中BOLD振幅变化模式表明显示重复抑制的海马-前额叶回路与显示持续激活的后内侧顶叶皮质之间存在分离。
