Yan Kai, Mu Chenglong, Zhang Cheng, Xu Qunna, Xu Zushun, Wang Daquan, Jing Xunan, Meng Lingjie
College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an 710021, PR China; School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an 710049, PR China.
College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an 710021, PR China.
J Colloid Interface Sci. 2022 Jun 15;616:759-768. doi: 10.1016/j.jcis.2022.02.042. Epub 2022 Feb 12.
The unsatisfactory efficacy of conventional theranostic agents in ablating tumor poses urgent demands on the development of high-performance integrated theranostic agents utilizing rising nanotechnology. To cope with the existing limitations, here we presented an intelligent nanoplatform based on yolk-shell FeO@polydopamine prepared by mussel-inspired polydopamine chemistry and sacrificial template method as well as subsequent incorporation of Pt nanoparticles and chlorine 6 (Ce6) by in situ reduction and electrostatic adsorption for photodynamic therapy (PDT) and photothermal (PTT). The resultant nanoplatform could effectively deliver photosensitizer Ce6 to tumor sites, then promoting the decomposition of endogenous HO to oxygen, finally achieving enhanced PDT therapy, which is demonstrated by in vitro and in vivo evaluations. Importantly, the generated oxygen bubbles could improve the echogenicity signal of yolk-shell microspheres and thereby provide enhanced ultrasonic (US) signal for imaging solid tumors. Overall, the synergistic combination of magnetic FeO, green polydopamine, catalytic Pt nanoparticles, photosensitive Ce6 enabled the hybrid nanoplatform to have good biocompatibility, efficient tumor accumulation, excellent phototherapy efficiency, high T-weighted magnetic resonance imaging (MRI) and fluorescence imaging ability (FL). Our study integrating the merits of PDT/PTT and US/MRI/FL into a single nanoplatform will open an avenue of therapeutic strategy toward biomedical applications.
传统诊疗试剂在消融肿瘤方面的疗效不尽人意，这对利用新兴纳米技术开发高性能集成诊疗试剂提出了迫切需求。为应对现有局限性，我们在此展示了一种基于蛋黄壳结构FeO@聚多巴胺的智能纳米平台，该平台通过受贻贝启发的聚多巴胺化学和牺牲模板法制备，随后通过原位还原和静电吸附引入铂纳米颗粒和氯6（Ce6）用于光动力疗法（PDT）和光热疗法（PTT）。所得纳米平台能够有效地将光敏剂Ce6递送至肿瘤部位，进而促进内源性过氧化氢分解产生氧气，最终实现增强的PDT治疗效果，体外和体内评估均证实了这一点。重要的是，产生的氧气气泡可以改善蛋黄壳微球的回声信号，从而为实体瘤成像提供增强的超声（US）信号。总体而言，磁性FeO、绿色聚多巴胺、催化性铂纳米颗粒和光敏性Ce6的协同组合使该混合纳米平台具有良好的生物相容性、高效的肿瘤蓄积、优异的光疗效率、高T加权磁共振成像（MRI）和荧光成像能力（FL）。我们将PDT/PTT与US/MRI/FL的优点整合到单个纳米平台中的研究将为生物医学应用开辟一条治疗策略途径。
