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死麻风分枝杆菌和其他分枝杆菌对调理酵母吞噬作用的影响。

The influence of killed Mycobacterium leprae and other mycobacteria on opsonized yeast phagocytosis.

作者信息

Cree I A, Beck J S

出版信息

Clin Exp Immunol. 1986 Apr;64(1):35-40.

PMID:3524918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542140/
Abstract

The influence of killed mycobacteria on the metabolic burst associated with phagocytosis of opsonized zymosan by normal human polymorphonuclear leucocytes (PMNL) or monocytes was studied by chemiluminescence (CL) measurements. M. leprae reproducibly reduced the peak and total CL of both types of phagocyte to a small, but highly significant extent. Electron microscopy showed that M. leprae were phagocytosed: cells with ingested or adherent M. leprae phagocytosed fewer zymosan particles. M. leprae did not cause aggregation of the phagocytes or quenching of CL. M. lepraemurium did not influence the CL response to zymosan. Addition of M. tuberculosis caused an increased response with PMNL but not with monocytes.

摘要

通过化学发光（CL）测量研究了灭活分枝杆菌对正常人多形核白细胞（PMNL）或单核细胞吞噬调理酵母聚糖相关代谢爆发的影响。麻风杆菌可重复性地将两种吞噬细胞的CL峰值和总量降低到较小但非常显著的程度。电子显微镜显示麻风杆菌被吞噬：摄入或附着有麻风杆菌的细胞吞噬的酵母聚糖颗粒较少。麻风杆菌不会导致吞噬细胞聚集或CL淬灭。鼠麻风杆菌不影响对酵母聚糖的CL反应。添加结核分枝杆菌会使PMNL的反应增强，但对单核细胞则不然。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d231/1542140/1687017e4154/clinexpimmunol00121-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d231/1542140/1687017e4154/clinexpimmunol00121-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d231/1542140/1687017e4154/clinexpimmunol00121-0047-a.jpg

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本文引用的文献

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Optimal conditions for simultaneous purification of mononuclear and polymorphonuclear leucocytes from human blood by the Hypaque-Ficoll method.使用聚蔗糖-泛影葡胺法从人血中同时纯化单核细胞和多形核白细胞的最佳条件。
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Superoxide dismutase, peroxidatic activity and catalase in Mycobacterium leprae purified from armadillo liver.从犰狳肝脏中纯化的麻风分枝杆菌中的超氧化物歧化酶、过氧化物酶活性和过氧化氢酶
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Clin Exp Immunol. 1982 Sep;49(3):517-22.
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Chemiluminescent response to pathogenic organisms: normal human polymorphonuclear leukocytes.对病原生物的化学发光反应：正常人类多形核白细胞
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Alterations in the membrane of macrophages from leprosy patients.麻风病人巨噬细胞膜的改变。
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Communication between receptors for different ligands on a single cell: ligation of fibronectin receptors induces a reversible alteration in the function of complement receptors on cultured human monocytes.单个细胞上不同配体的受体之间的通讯：纤连蛋白受体的连接可诱导培养的人单核细胞上补体受体功能发生可逆性改变。
J Cell Biol. 1984 Jul;99(1 Pt 1):336-9. doi: 10.1083/jcb.99.1.336.
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Toxic effect of the peroxidase-hydrogen peroxide-halide antimicrobial system on Mycobacterium leprae.过氧化物酶-过氧化氢-卤化物抗菌系统对麻风分枝杆菌的毒性作用。
Infect Immun. 1984 May;44(2):534-6. doi: 10.1128/iai.44.2.534-536.1984.
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Adv Exp Med Biol. 1982;155:687-93. doi: 10.1007/978-1-4684-4394-3_75.