Institute of Cell Biophysics of the Russian Academy of Sciences, 142290, Pushchino, Russia.
Rev Neurosci. 2022 Mar 4;33(6):641-655. doi: 10.1515/revneuro-2021-0144. Print 2022 Aug 26.
Kainate receptors (KARs) are considered one of the key modulators of synaptic activity in the mammalian central nervous system. These receptors were discovered more than 30 years ago, but their role in brain functioning remains unclear due to some peculiarities. One such feature of these receptors is the editing of pre-mRNAs encoding GluK1 and GluK2 subunits. Despite the long history of studying this phenomenon, numerous questions remain unanswered. This review summarizes the current data about the mechanism and role of pre-mRNA editing of KAR subunits in the mammalian brain and proposes a perspective of future investigations.
kainate 受体（KARs）被认为是哺乳动物中枢神经系统中突触活动的关键调节剂之一。这些受体在 30 多年前被发现，但由于一些特殊性，它们在大脑功能中的作用仍不清楚。这些受体的一个特点是对编码 GluK1 和 GluK2 亚基的 pre-mRNAs 进行编辑。尽管对这种现象的研究已有很长的历史，但仍有许多问题尚未得到解答。本综述总结了目前关于哺乳动物脑内 KAR 亚基 pre-mRNA 编辑的机制和作用的相关数据，并提出了未来研究的展望。
