中性粒细胞与淋巴细胞比值及乳酸脱氢酶对马尔尼菲篮状菌感染艾滋病患者的早期诊断价值。

Neutrophil-to-lymphocyte ratio and lactate dehydrogenase for early diagnosis of AIDS patients with Talaromyces marneffei infection.

机构信息

Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, the First Affiliated Hospital of Guangxi Medical University, Nanning, China; Department of Clinical Laboratory, the People's Hospital of Baise, Baise, China.

Department of Clinical Laboratory, the People's Hospital of Baise, Baise, China.

出版信息

Ann Palliat Med. 2022 Feb;11(2):588-597. doi: 10.21037/apm-22-36.

DOI:10.21037/apm-22-36

PMID:35249337

Abstract

BACKGROUND

This study aimed to explore the value of neutrophil-to-lymphocyte ratio (NLR) in combination with routine blood tests, lactate dehydrogenase (LDH), and T-lymphocyte subsets for the early diagnosis of acquired immunodeficiency syndrome (AIDS) combined with Talaromyces marneffei (TM) infection.

METHODS

A total of 166 confirmed AIDS patients were enrolled in this study. The observation group included 80 AIDS patients with TM infection, and the control group consisted of 86 AIDS patients with other complications. Regression analysis was performed to evaluate the predictive value of each index and the combination of these indexes for AIDS combined with TM infection using receiver operating characteristic (ROC) curve analysis.

RESULTS

NLR and LDH were significantly higher in patients in the observation group compared with those in the control group, and the differences were statistically significant (P<0.05). There was no statistical difference in platelets, infantile granulocytes (IGM), and nucleated red blood cells (NRBC) between the 2 groups (P>0.05). The area under the operating characteristic curve (AUC) of the observed indicators were: NLR, 0.628; hemoglobin (HGB), 0.704; LDH, 0.607; lymphocyte (LYM) count, 0.744; CD4+ T lymphocyte count, 0.789; and CD8+ T lymphocyte count, 0.701. The combined AUC of multiple indicators was 0.815, with a sensitivity and specificity of 76.2% and 76.1%, respectively.

CONCLUSIONS

NLR, HGB, LYM, LDH, and T lymphocyte subsets were diagnostic for early AIDS combined with TM infection , and CD4+ T lymphocytes had the best diagnostic efficacy alone.

摘要

背景

本研究旨在探讨中性粒细胞与淋巴细胞比值（NLR）联合常规血液检查、乳酸脱氢酶（LDH）和 T 淋巴细胞亚群在诊断获得性免疫缺陷综合征（AIDS）合并马尔尼菲青霉（TM）感染中的价值。

方法

共纳入 166 例确诊 AIDS 患者，观察组为 80 例 AIDS 合并 TM 感染者，对照组为 86 例 AIDS 合并其他并发症者。采用回归分析评价各指标及联合指标对 AIDS 合并 TM 感染的预测价值，采用受试者工作特征（ROC）曲线分析。

结果

观察组患者 NLR 和 LDH 明显高于对照组，差异有统计学意义（P<0.05）。两组患者血小板、幼稚粒细胞（IGM）、有核红细胞（NRBC）比较，差异无统计学意义（P>0.05）。观察指标的曲线下面积（AUC）分别为：NLR 为 0.628；血红蛋白（HGB）为 0.704；LDH 为 0.607；淋巴细胞（LYM）计数为 0.744；CD4+T 淋巴细胞计数为 0.789；CD8+T 淋巴细胞计数为 0.701。多指标联合 AUC 为 0.815，灵敏度和特异度分别为 76.2%和 76.1%。