Wang Nannan, Zeng Ting
Nannan Wang Department of Laboratory Medicine, Taihe County People's Hospital, Taihe, Anhui Province, 236600, P.R. China.
Ting Zeng, Department of First Class Ward, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, 510000, P.R. China.
Pak J Med Sci. 2024 Nov;40(10):2233-2237. doi: 10.12669/pjms.40.10.9895.
To explore the expression characteristics and clinical value of immune function indicators in patients with human immunodeficiency virus (HIV) infection.
In this retrospective study, clinical data of 196 patients with HIV infection (observation group) and 196 health examinees (control group) admitted to our hospital from November 2021 to March 2023 were retrospectively analyzed. Patients in the observation group were further classified based on the staging as acute phase (n=53), asymptomatic phase (n=65), and acquired immunodeficiency (AIDS) phase (n=78). Levels of immune function indicators in the observation group and the control group were compared, and the correlation between immune function index levels and disease staging was analyzed.
Levels of CD3, CD4, CD4/CD8, B cells, and NK cells were lower in the observation group (P<0.05), were significantly lower in asymptomatic patients compared with patients in the acute phase (P<0.05), and were significantly lower in patients with AIDS than those in asymptomatic patients (P<0.05). The results for CD8 were in contrast to the above(P<0.05). Spearman analysis confirmed that levels of CD3, CD4, CD4/CD8, B cells and NK cells significantly negatively correlated, and levels of CD8+ significantly positively correlated with the stages of HIV (P<0.05).
The immune function indicators of patients with HIV infection are markedly abnormal, which is mainly manifested by the decreased levels of CD3, CD4, CD4/CD8, B cells and NK cells, and the increased levels of CD8. The profile of the immune function indicators correlates with the progressive severity of the disease.
探讨人类免疫缺陷病毒（HIV）感染患者免疫功能指标的表达特征及临床价值。
本回顾性研究对2021年11月至2023年3月我院收治的196例HIV感染患者（观察组）和196例健康体检者（对照组）的临床资料进行回顾性分析。观察组患者根据分期进一步分为急性期（n = 53）、无症状期（n = 65）和获得性免疫缺陷综合征（AIDS）期（n = 78）。比较观察组和对照组免疫功能指标水平，并分析免疫功能指标水平与疾病分期的相关性。
观察组CD3、CD4、CD4/CD8、B细胞和NK细胞水平较低（P < 0.05），无症状患者与急性期患者相比显著降低（P < 0.05），AIDS患者与无症状患者相比显著降低（P < 0.05）。CD8的结果与上述情况相反（P < 0.05）。Spearman分析证实，CD3、CD4、CD4/CD8、B细胞和NK细胞水平与HIV分期呈显著负相关，CD8+水平与HIV分期呈显著正相关（P < 0.05）。
HIV感染患者的免疫功能指标明显异常，主要表现为CD3、CD4、CD4/CD8、B细胞和NK细胞水平降低，CD8水平升高。免疫功能指标的变化与疾病进展的严重程度相关。
