Shanghai Key Laboratory of Maternal Fetal Medicine, Department of Fetal Medicine & Prenatal Diagnosis Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Twin Res Hum Genet. 2022 Feb;25(1):50-55. doi: 10.1017/thg.2022.1. Epub 2022 Mar 7.
The aim of this study was to determine the pregnancy loss rate of amniocentesis with double-needle insertions in twin pregnancies. This was a retrospective study of twin pregnancies who underwent amniocentesis with double-needle insertion between 2010 and 2019 at a single center. The pregnancy loss rates were recorded as single or double fetal loss before 24 weeks' gestation and within 4 weeks after the procedure. Risk factors for pregnancy loss after amniocentesis were also assessed. A total of 678 twin pregnancies with amniocentesis were finally included. The pregnancy loss rates before 24 weeks' gestation and within 4 weeks after the procedure were 0.9% and 1.9%, respectively. Only one fetal loss was presumed to be a direct result of the procedure. All other cases were complicated by structural or chromosomal anomalies. Twin pregnancies with abnormal ultrasound findings had a significantly higher rate of pregnancy loss with a relative risk of 4.81 (95% CI [1.03, 22.2]). Our study showed a low pregnancy loss rate after amniocentesis in twin pregnancies with double-needle insertions technique of sampling, which can help decision making in prenatal screening and diagnosis for twin pregnancies.
本研究旨在确定双针穿刺羊膜腔穿刺术在双胎妊娠中的流产率。这是一项回顾性研究，纳入了 2010 年至 2019 年在一家单中心接受双针穿刺羊膜腔穿刺术的双胎妊娠患者。记录了 24 周前和术后 4 周内的单胎或双胎流产率。还评估了羊膜腔穿刺术后流产的风险因素。最终纳入了 678 例双胎妊娠接受羊膜腔穿刺术的患者。24 周前的流产率和术后 4 周内的流产率分别为 0.9%和 1.9%。仅 1 例胎儿丢失被认为是直接由该操作引起的。其他所有病例均伴有结构或染色体异常。超声检查发现异常的双胎妊娠流产率显著升高，相对风险为 4.81（95%CI[1.03，22.2]）。我们的研究显示，双针穿刺取样技术的双胎妊娠羊膜腔穿刺术后流产率较低，这有助于双胎妊娠的产前筛查和诊断决策。
