Charlier J, Bartley D J, Sotiraki S, Martinez-Valladares M, Claerebout E, von Samson-Himmelstjerna G, Thamsborg S M, Hoste H, Morgan E R, Rinaldi L
Kreavet, Kruibeke, Belgium.
Disease Control, Moredun Research Institute, Penicuik, United Kingdom.
Adv Parasitol. 2022;115:171-227. doi: 10.1016/bs.apar.2021.12.002. Epub 2022 Feb 10.
Anthelmintic resistance (AR) is a growing concern for effective parasite control in farmed ruminants globally. Combatting AR will require intensified and integrated research efforts in the development of innovative diagnostic tests to detect helminth infections and AR, sustainable anthelmintic treatment strategies and the development of complementary control approaches such as vaccination and plant-based control. It will also require a better understanding of socio-economic drivers of anthelmintic treatment decisions, in order to support a behavioural shift and develop targeted communication strategies that promote the uptake of evidence-based sustainable solutions. Here, we review the state-of-the-art in these different fields of research activity related to AR in helminths of livestock ruminants in Europe and beyond. We conclude that in the advent of new challenges and solutions emerging from continuing spread of AR and intensified research efforts, respectively, there is a strong need for transnational multi-actor initiatives. These should involve all key stakeholders to develop indicators of infection and sustainable control, set targets and promote good practices to achieve them.
抗蠕虫药耐药性（AR）日益成为全球养殖反刍动物有效控制寄生虫的一大担忧。应对AR需要在开发用于检测蠕虫感染和AR的创新诊断测试、可持续的驱虫治疗策略以及开发疫苗接种和植物源控制等补充控制方法方面加强和整合研究工作。这还需要更好地理解驱虫治疗决策的社会经济驱动因素，以支持行为转变并制定有针对性的沟通策略，促进采用基于证据的可持续解决方案。在此，我们综述了欧洲及其他地区与反刍动物家畜蠕虫AR相关的这些不同研究领域的最新进展。我们得出结论，鉴于AR持续传播带来的新挑战以及分别因加强研究工作而出现的新解决方案，迫切需要跨国多行为体倡议。这些倡议应让所有关键利益相关者参与进来，以制定感染和可持续控制指标、设定目标并推广实现这些目标的良好做法。
