Univ. Lille, Inserm, CHU Lille, Lille Neurosciences and Cognition, F-59000, Lille, France.
Univ. Lille, Inserm, CHU Lille, Lille Neurosciences and Cognition, F-59000, Lille, France; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UMS 2014 - PLBS, F-59000, Lille, France.
Parkinsonism Relat Disord. 2022 Feb;95:122-137. doi: 10.1016/j.parkreldis.2022.02.006. Epub 2022 Feb 17.
Mild cognitive impairment in Parkinson's disease (PD-MCI) is heterogenous and cognitive subtypes have been identified. However, the anatomo-functional bases of each subtype remain partly unknown.
To propose a description of the current literature on neuroimaging findings associated with cognitive subtypes of PD-MCI.
PubMed/Medline, Embase, PsycINFO and the Cochrane Library databases were searched (until April 2021). Studies comparing PD-MCI cognitive subtypes with healthy controls (HC) and PD patients with normal cognition (PD-NC) on any neuroimaging outcome were included.
Ten studies met the inclusion criteria. Six used structural MRI methods, two functional MRI methods, one electroencephalography and five positron or single-photon emission tomography. Most studies (n = 8) determined PD-MCI subtypes based on memory impairment and two based on executive impairment. Compared with HC and/or PD-NC, brain modifications were found in PD patients (a) with amnestic MCI and, to a lesser extent, non-amnestic MCI in occipital, parietal and temporal regions, (b) with executive MCI in frontal and striatal regions and (c) with non-executive MCI in posterior cortical regions.
Very few neuroimaging studies have considered cognitive heterogeneity that exists within PD-MCI, making it difficult to draw robust conclusions regarding brain modifications associated with specific subtypes. Given the promising potential of neuroimaging methods in both clinical practice and research, further studies are needed to overcome the limitations of the current literature.
帕金森病患者的轻度认知障碍（PD-MCI）具有异质性，并且已经确定了认知亚型。然而，每种亚型的解剖-功能基础仍部分未知。
提出与 PD-MCI 认知亚型相关的神经影像学研究的当前文献描述。
在 PubMed/Medline、Embase、PsycINFO 和 Cochrane Library 数据库中进行检索（截至 2021 年 4 月）。纳入了比较 PD-MCI 认知亚型与健康对照者（HC）和认知正常的帕金森病患者（PD-NC）在任何神经影像学结果上的差异的研究。
符合纳入标准的研究有 10 项。其中 6 项使用结构 MRI 方法，2 项使用功能 MRI 方法，1 项使用脑电图，5 项使用正电子或单光子发射断层扫描。大多数研究（n=8）根据记忆障碍确定 PD-MCI 亚型，有 2 项研究根据执行障碍确定。与 HC 和/或 PD-NC 相比，在 PD 患者中发现了脑区改变：（a）有遗忘型 MCI，在枕叶、顶叶和颞叶区域，程度较轻的非遗忘型 MCI；（b）有执行障碍型 MCI，在前额和纹状体区域；（c）有非执行障碍型 MCI，在后皮质区域。
很少有神经影像学研究考虑到 PD-MCI 内存在的认知异质性，因此难以得出与特定亚型相关的脑区改变的可靠结论。鉴于神经影像学方法在临床实践和研究中具有很大的应用潜力，需要进一步研究以克服当前文献的局限性。
