UNLABELLED: Curcumin, the major bioactive component of turmeric () was microencapsulated by spray drying in the matrix of HI-CAP 100 (resistant starch)/ maltodextrin and whey protein isolate to improve its oral bioavailability and solubility. Taguchi orthogonal array design (L) was used to optimize the spray drying conditions. The optimal conditions for microencapsulation were inlet drying air temperature of 185 °C, feed rate of 6 mL/min and HI-CAP 100 as wall material. The moisture content, encapsulation efficiency and bulk density at these conditions were 4.65%, 82.42% and 358.40 kg/m, respectively. The spray-dried microcapsules were spherical-shaped with folds and vacuoles. The yellowness index and a value of curcumin decreased after microencapsulation. FTIR spectroscopy indicated that the curcumin after microencapsulation presumably retained its chemical structure. DSC thermograms confirmed that the microcapsules were heat stable up to 200 °C. The microcapsules had better heat stability and sustained release as compared to that of pure curcumin. The DPPH free radical scavenging activity of curcumin was 61.43%, which was largely unaffected after microencapsulation. Fortification of milk with HI-CAP 100-based microcapsules at the selected dose had no adverse effect on organoleptic properties as compared to normal milk. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13197-021-05142-0.