Institute of Pharmaceutical Technologies, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, Kaunas LT-50161, Lithuania.
Department of Drug Technology and Social Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, Kaunas LT-50161, Lithuania.
Molecules. 2019 Apr 13;24(8):1461. doi: 10.3390/molecules24081461.
Spray-drying is the most popular encapsulation method used for the stabilization and protection of biologically active compounds from various environmental conditions, such as oxidation, moisture, pH, and temperature. Spray-drying increases the bioavailability of the natural active compounds and improves the solubility of low-soluble compounds. The aim of this work was to study the effects of different wall materials and optimize wall material solution's composition on physicochemical properties of microcapsules loaded with phenolics, extract rich in volatile compounds and essential oil from herb. For encapsulation of elsholtzia and dehydroelsholtzia ketones, more suitable wall materials were used-beta-cyclodextrin and sodium caseinate. Four phenolics-sodium caseinate, skim milk, beta-cyclodextrin, and resistant-maltodextrin-were used. A D-optimal mixture composition design was used to evaluate the effect of wall material solution's composition using sodium caseinate (0.5-1 g), skim milk (6-10 g), resistant-maltodextrin (8-12 g), and beta-cyclodextrin (0.5-1 g) for the encapsulation efficiency, drying yield, and physicochemical properties. The optimal mixture composition was 0.54 g of sodium caseinate, 10 g of skim milk, 8.96 g of resistant-maltodextrin, and 0.5 g of beta-cyclodextrin. These encapsulating agents had a good performance in the microencapsulation of ethanolic extracts by the spray-drying technique. It is proven that the produced microparticles have a good potential to be included in various pharmaceutical forms or food supplements.
喷雾干燥是最常用的封装方法，用于稳定和保护各种生物活性化合物免受环境条件的影响，如氧化、湿度、pH 值和温度。喷雾干燥提高了天然活性化合物的生物利用度，并提高了低溶解度化合物的溶解度。本工作旨在研究不同壁材的影响，并优化壁材溶液的组成，以研究负载酚类化合物、富含挥发性化合物和草药精油的微胶囊的物理化学性质。为了包埋荆芥和脱水荆芥酮，使用了更合适的壁材-β-环糊精和酪蛋白酸钠。使用了四种酚类化合物-酪蛋白酸钠、脱脂乳、β-环糊精和抗性麦芽糊精。使用 D-最优混合成分设计来评估壁材溶液组成对包封效率、干燥产率和物理化学性质的影响，使用的壁材溶液组分为酪蛋白酸钠（0.5-1 g）、脱脂乳（6-10 g）、抗性麦芽糊精（8-12 g）和β-环糊精（0.5-1 g）。最佳混合成分是 0.54 g 酪蛋白酸钠、10 g 脱脂乳、8.96 g 抗性麦芽糊精和 0.5 g β-环糊精。这些包封剂在喷雾干燥技术对醇提物的微胶囊化中表现出良好的性能。事实证明，所制备的微颗粒具有很好的潜力，可以包含在各种药物形式或食品补充剂中。
