Pogodalla Nicole, Winkler Bente, Klämbt Christian
Institute for Neuro- and Behavioral Biology, University of Münster, Münster, Germany.
Front Cell Neurosci. 2022 Feb 17;16:825695. doi: 10.3389/fncel.2022.825695. eCollection 2022.
The Drosophila nervous system comprises a small number of well characterized glial cell classes. The outer surface of the central nervous system (CNS) is protected by a glial derived blood-brain barrier generated by perineurial and subperineurial glia. All neural stem cells and all neurons are engulfed by cortex glial cells. The inner neuropil region, that harbors all synapses and dendrites, is covered by ensheathing glia and infiltrated by astrocyte-like glial cells. All these glial cells show a tiled organization with an often remarkable plasticity where glial cells of one cell type invade the territory of the neighboring glial cell type upon its ablation. Here, we summarize the different glial tiling patterns and based on the different modes of cell-cell contacts we hypothesize that different molecular mechanisms underlie tiling of the different glial cell types.
果蝇的神经系统由少数特征明确的神经胶质细胞类型组成。中枢神经系统（CNS）的外表面由神经束膜和神经束膜下神经胶质细胞产生的神经胶质衍生的血脑屏障保护。所有神经干细胞和所有神经元都被皮质神经胶质细胞吞噬。包含所有突触和树突的内部神经纤维区域被包被神经胶质细胞覆盖，并被星形胶质样神经胶质细胞浸润。所有这些神经胶质细胞都呈现出一种镶嵌式组织，通常具有显著的可塑性，即一种细胞类型的神经胶质细胞在邻近细胞类型的神经胶质细胞被切除后会侵入其区域。在这里，我们总结了不同的神经胶质镶嵌模式，并基于不同的细胞间接触模式，推测不同的分子机制是不同神经胶质细胞类型镶嵌的基础。
