血流限制运动对健康成年人骨骼肌血管生成相关因子的影响：一项系统评价与Meta分析
The Effect of Blood Flow Restriction Exercise on Angiogenesis-Related Factors in Skeletal Muscle Among Healthy Adults: A Systematic Review and Meta-Analysis.
作者信息
Li Shuoqi, Li Shiming, Wang Lifeng, Quan Helong, Yu Wenbing, Li Ting, Li Wei
机构信息
School of Health Science, Universiti Sains Malaysia, Kelantan, Malaysia.
Institute of Sports Human Science, Ocean University of China, Shandong, China.
出版信息
Front Physiol. 2022 Feb 17;13:814965. doi: 10.3389/fphys.2022.814965. eCollection 2022.
BACKGROUND
Blood flow restriction (BFR) exercise may be a potential exercise program to promote angiogenesis. This review aims to compare the effects of exercise with and without BFR on angiogenesis-related factors in skeletal muscle among healthy adults.
METHODOLOGY
Searches were made in Web of Science, Scopus, PubMed, and EBSCO databases from January 2001 to June 2021. Studies were screened, quality was evaluated, and data were extracted. The review protocol was registered at PROSPERO (PROSPERO registration number: CRD42021261367). Standardized mean differences (SMD) of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor 2 (VEGFR-2), hypoxia inducible factor 1α (HIF-1α), peroxisome proliferator-activated receptorγcoactivator-1α (PGC-1α) and endothelial nitric oxide synthase (eNOS) were analyzed using Revman 5.4 software with a 95% confidence interval (95% CI).
RESULTS
Ten studies fulfilled the inclusion criteria with a total of 75 participants for BFR group and 77 for CON group. BFR exercise elicits greater expression of VEGF (heterogeneity test, = 0.09, I = 44%; SMD, 0.93 [0.38, 1.48], < 0.05), VEGFR-2 (heterogeneity test, = 0.81, I = 0%; SMD, 0.64 [0.08, 1.21], < 0.05), HIF-1α (heterogeneity test, = 0.67, I = 0%; SMD, 0.43 [0.03, 0.82], < 0.05), PGC-1α (heterogeneity test, = 0.02, I = 54%; SMD, 0.74 [0.21, 1.28], < 0.05) and eNOS (heterogeneity test, = 0.88, I = 0%; SMD, 0.60 [0.04, 1.17], < 0.05) mRNA than non-BFR exercise. In the sub-group analysis, resistance exercise with BFR elicits greater expression of VEGF (heterogeneity test, = 0.36, I = 6%; SMD, 1.66 [0.97, 2.35], < 0.05) and HIF-1α (heterogeneity test, = 0.56, I = 0%; SMD, 0.51 [0.01, 1.02], < 0.05) mRNA than aerobic exercise with BFR.
CONCLUSION
Exercise with BFR elicited more angiogenesis-related factors mRNA expression than exercise without BFR, but not VEGF and PGC-1α protein expression. Therefore, BFR training may be a potential training program to improve vascular function.
SYSTEMATIC REVIEW REGISTRATION
[https://www.crd.york.ac.uk/prospero/], identifier [CRD42021261367].
背景
血流限制（BFR）运动可能是一种促进血管生成的潜在运动方案。本综述旨在比较有和没有BFR的运动对健康成年人骨骼肌中血管生成相关因子的影响。
方法
于2001年1月至2021年6月在Web of Science、Scopus、PubMed和EBSCO数据库中进行检索。对研究进行筛选、评估质量并提取数据。该综述方案已在PROSPERO注册（PROSPERO注册号：CRD42021261367）。使用Revman 5.4软件分析血管内皮生长因子（VEGF）、血管内皮生长因子受体2（VEGFR-2）、缺氧诱导因子1α（HIF-1α）、过氧化物酶体增殖物激活受体γ辅激活因子-1α（PGC-1α）和内皮型一氧化氮合酶（eNOS）的标准化平均差（SMD），置信区间为95%（95%CI）。
结果
10项研究符合纳入标准，BFR组共有75名参与者，对照组有77名。与无BFR运动相比，BFR运动引起VEGF（异质性检验， = 0.09，I = 44%；SMD，0.93[0.38，1.48]， < 0.05）、VEGFR-2（异质性检验， = 0.81，I = 0%；SMD，0.64[0.08，1.21]， < 0.05）、HIF-1α（异质性检验， = 0.67，I = 0%；SMD，0.43[0.03，0.82]， < 0.05）、PGC-1α（异质性检验， = 0.02，I = 54%；SMD，0.74[0.21，1.28]， < 0.05）和eNOS（异质性检验， = 0.88，I = 0%；SMD，0.60[0.04，1.17]， < 0.05）mRNA表达更高。在亚组分析中，与有BFR的有氧运动相比，有BFR的抗阻运动引起VEGF（异质性检验， = 0.36，I = 6%；SMD，1.66[0.97，2.35]， < 0.05）和HIF-1α（异质性检验， = 0.56，I = 0%；SMD，0.51[0.01，1.02]， < 0.05）mRNA表达更高。
结论
与无BFR的运动相比，有BFR的运动引起更多血管生成相关因子mRNA表达，但未引起VEGF和PGC-1α蛋白表达。因此，BFR训练可能是一种改善血管功能的潜在训练方案。
系统评价注册
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