Chronic kidney disease (CKD) has become a widespread disease among people. It is related to various serious risks like cardiovascular disease, heightened risk, and end-stage renal disease, which can be feasibly avoidable by early detection and treatment of people in danger of this disease. The machine learning algorithm is a source of significant assistance for medical scientists to diagnose the disease accurately in its outset stage. Recently, Big Data platforms are integrated with machine learning algorithms to add value to healthcare. Therefore, this paper proposes hybrid machine learning techniques that include feature selection methods and machine learning classification algorithms based on big data platforms (Apache Spark) that were used to detect chronic kidney disease (CKD). The feature selection techniques, namely, Relief-F and chi-squared feature selection method, were applied to select the important features. Six machine learning classification algorithms were used in this research: decision tree (DT), logistic regression (LR), Naive Bayes (NB), Random Forest (RF), support vector machine (SVM), and Gradient-Boosted Trees (GBT Classifier) as ensemble learning algorithms. Four methods of evaluation, namely, accuracy, precision, recall, and F1-measure, were applied to validate the results. For each algorithm, the results of cross-validation and the testing results have been computed based on full features, the features selected by Relief-F, and the features selected by chi-squared feature selection method. The results showed that SVM, DT, and GBT Classifiers with the selected features had achieved the best performance at 100% accuracy. Overall, Relief-F's selected features are better than full features and the features selected by chi-square.