Xu Rui, Fang Xinnan, Wu Shengqian, Wang Yiyin, Zhong Yi, Hou Ruixia, Zhang Libing, Shao Lei, Pang Qian, Zhang Jian, Cui Xiang, Zuo Rongyue, Yao Liwei, Zhu Yabin
The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
School of Medicine, Ningbo University, Ningbo, China.
Front Bioeng Biotechnol. 2022 Feb 17;10:853193. doi: 10.3389/fbioe.2022.853193. eCollection 2022.
Currently, patients with esophageal cancer, especially advanced patients, usually use autologous tissue for esophageal alternative therapy. However, an alternative therapy is often accompanied by serious complications such as ischemia and leakage, which seriously affect the prognosis of patients. Tissue engineering has been widely studied as one of the ideal methods for the treatment of esophageal cancer. In view of the complex multi-layer structure of the natural esophagus, how to use the tissue engineering method to design the scaffold with structure and function matching with the natural tissue is the principle that the tissue engineering method must follow. This article will analyze and summarize the construction methods, with or without cells, and repair effects of single-layer scaffold and multi-layer scaffold. Especially in the repair of full-thickness and circumferential esophageal defects, the flexible design method and the binding force between the layers of the scaffold are very important. In short, esophageal tissue engineering technology has broad prospects and plays a more and more important role in the treatment of esophageal diseases.
目前，食管癌患者，尤其是晚期患者，通常使用自体组织进行食管替代治疗。然而，替代治疗往往伴随着诸如缺血和渗漏等严重并发症，这严重影响患者的预后。组织工程作为治疗食管癌的理想方法之一已得到广泛研究。鉴于天然食管复杂的多层结构，如何利用组织工程方法设计出结构和功能与天然组织相匹配的支架是组织工程方法必须遵循的原则。本文将分析和总结单层支架和多层支架有细胞或无细胞的构建方法及修复效果。特别是在全层和环形食管缺损的修复中，支架的灵活设计方法及各层之间的结合力非常重要。总之，食管组织工程技术具有广阔前景，在食管疾病治疗中发挥着越来越重要的作用。
