Li Qing, Song Wei, Li Jinghui, Ma Chuying, Zhao Xinxiang, Jiao Jianlin, Mrowczynski Oliver, Webb Becky S, Rizk Elias B, Lu Di, Liu Chao
Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming, 650500, China.
Aleo BME, Inc., State College, PA 16803, USA.
Matter. 2022 Mar 2;5(3):933-956. doi: 10.1016/j.matt.2021.12.018. Epub 2022 Jan 25.
Existing tissue adhesives and sealants are far from satisfactory when applied on wet and dynamic tissues. Herein, we report a strategy for designing biodegradable super-strong aqueous glue (B-Seal) for surgical uses inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super-strong, and elastic adhesive sealant composed of injectable water-borne biodegradable polyurethane (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than DuraSeal®, 138-fold greater T-pull adhesive strength than fibrin glue, and 16-fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective CSF leak prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction of designing the next-generation wet tissue adhesives for surgeries.
现有的组织粘合剂和密封剂应用于湿润和动态组织时远不能令人满意。在此，我们报告一种受常春藤粘附策略和水泥颗粒堆积理论启发的用于手术的可生物降解超强水性胶水（B-Seal）的设计策略。B-Seal是一种快速凝胶化、超强且有弹性的粘合剂密封剂，由在其A-B配方中具有不匹配粒径和抗衡离子的可注射水性可生物降解聚氨酯（WPU）纳米分散体组成。B-Seal的破裂压力比DuraSeal®高24倍，T型拉伸粘合强度比纤维蛋白胶高138倍，搭接剪切强度比纤维蛋白胶高16倍。在大鼠脑脊液（CSF）鼻漏模型和猪开颅模型上的体内评估验证了B-Seal在有效预防CSF漏和硬脑膜修复方面的安全性和有效性。受植物启发的粘附策略与颗粒堆积理论相结合，代表了设计下一代手术用湿组织粘合剂的新方向。
