Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain.
Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), E-08003 Barcelona, Spain.
FEMS Yeast Res. 2022 Mar 25;22(1). doi: 10.1093/femsyr/foac013.
Cells coordinate intracellular activities in response to changes in the extracellular environment to maximize their probability of survival and proliferation. Eukaryotic cells need to adapt to constant changes in the osmolarity of their environment. In yeast, the high-osmolarity glycerol (HOG) pathway is responsible for the response to high osmolarity. Activation of the Hog1 stress-activated protein kinase (SAPK) induces a complex program required for cellular adaptation that includes temporary arrest of cell cycle progression, adjustment of transcription and translation patterns, and the regulation of metabolism, including the synthesis and retention of the compatible osmolyte glycerol. Hog1 is a member of the family of p38 SAPKs, which are present across eukaryotes. Many of the properties of the HOG pathway and downstream-regulated proteins are conserved from yeast to mammals. This review addresses the global view of this signaling pathway in yeast, as well as the contribution of Dr Hohmann's group to its understanding.
细胞响应细胞外环境的变化来协调细胞内活动，从而最大限度地提高其生存和增殖的概率。真核细胞需要适应其环境渗透压的持续变化。在酵母中，高渗透压甘油（HOG）途径负责对高渗透压的响应。hog1 应激激活蛋白激酶（SAPK）的激活诱导了细胞适应所需的复杂程序，包括细胞周期进程的暂时停止、转录和翻译模式的调整以及代谢的调节，包括相容渗透物甘油的合成和保留。hog1 是 p38 SAPK 家族的成员，存在于所有真核生物中。从酵母到哺乳动物，HOG 途径和下游调节蛋白的许多特性都是保守的。这篇综述介绍了酵母中这一信号通路的全局视图，以及霍夫曼博士小组对其理解的贡献。
