ATG1/ATG13 激酶复合物在植物中的新兴作用。

The emerging roles of ATG1/ATG13 kinase complex in plants.

机构信息

Key Laboratory of Cell Activities and Stress Adaptations, Ministry of Education, School of Life Sciences, Lanzhou University, Lanzhou, 730000, People's Republic of China.

出版信息

J Plant Physiol. 2022 Apr;271:153653. doi: 10.1016/j.jplph.2022.153653. Epub 2022 Mar 2.

DOI:10.1016/j.jplph.2022.153653

PMID:35255243

Abstract

Autophagy is a conserved system from yeast to mammals that mediates the degradation and renovation of cellular components. This process is mainly driven by numerous autophagy-related (ATG) proteins. Among these components, the ATG1/ATG13 complex plays an essential role in initiating autophagy, sensing nutritional status signals, recruiting downstream ATG proteins to the autophagosome formation site, and governing autophagosome formation. In this review, we will focus on the ATG1/ATG13 kinase complex, summarizing and discussing the current views on the composition, structure, function, and regulation of this complex in plants.

摘要

自噬是一种从酵母到哺乳动物中保守的系统，介导细胞成分的降解和更新。这个过程主要由许多自噬相关（ATG）蛋白驱动。在这些成分中，ATG1/ATG13 复合物在启动自噬、感知营养状态信号、招募下游 ATG 蛋白到自噬体形成位点以及控制自噬体形成方面起着至关重要的作用。在这篇综述中，我们将重点介绍 ATG1/ATG13 激酶复合物，总结和讨论目前对该复合物在植物中的组成、结构、功能和调节的观点。