Department of Pediatrics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Children's Clinic, Tartu University Hospital, Tartu, Estonia.
Endocrinol Metab (Seoul). 2022 Feb;37(1):175-179. doi: 10.3803/EnM.2021.1262. Epub 2022 Feb 28.
The incidence of type 1 diabetes (T1D) is increasing throughout the world. This trend may be explained by the accelerator hypothesis. Our study investigated growth, its biochemical markers, and their associations with the development of diabetes-associated autoantibodies (DAAB) in 219 children with genetic risk for T1D. Subjects were divided into risk groups based on their human leukocyte antigen genotype. Children in the moderate- to high-risk group were significantly taller when corrected to mid-parental height and had a lower insulin-like growth factor 1 (IGF-1)/IGF-1 binding protein (IGFBP-3) molar ratio than those in the low-risk group (corrected height standard deviation score 0.22±0.93 vs. -0.04±0.84, P<0.05; molar ratio 0.199±0.035 vs. 0.211+0.039, P<0.05). Children with DAAB tended to be taller and to have a higher body mass index than those with no DAAB. Our results suggest that the accelerator hypothesis explaining the increasing incidence of T1D may not solely be dependent on environmental factors, but could be partially genetically determined.
1 型糖尿病（T1D）的发病率在全球范围内呈上升趋势。这种趋势可以用加速器假说来解释。我们的研究调查了 219 名具有 T1D 遗传风险的儿童的生长、其生化标志物及其与糖尿病相关自身抗体（DAAB）发展的关系。根据人类白细胞抗原基因型将受试者分为风险组。与低风险组相比，中高危组的儿童校正至中亲身高时明显更高，胰岛素样生长因子 1（IGF-1）/IGF-1 结合蛋白（IGFBP-3）摩尔比更低（校正身高标准差评分 0.22±0.93 与-0.04±0.84，P<0.05；摩尔比 0.199±0.035 与 0.211+0.039，P<0.05）。有 DAAB 的儿童往往比没有 DAAB 的儿童更高，体重指数也更高。我们的结果表明，解释 T1D 发病率上升的加速器假说可能不仅仅取决于环境因素，而可能部分是由遗传决定的。
