Alzoughool Foad, Abumweis Suhad, Alanagreh Lo'ai, Atoum Manar
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan.
Faculty of Health Sciences, Higher Colleges of Technology, Fujairah Women's College, Fujairah, United Arab Emirates.
Osong Public Health Res Perspect. 2022 Feb;13(1):37-50. doi: 10.24171/j.phrp.2021.0186. Epub 2022 Feb 18.
The aim of this study was to evaluate the association of pre-existing cardiovascular comorbidities, including hypertension and coronary heart disease, with coronavirus disease 2019 (COVID-19) severity and mortality.
PubMed, ScienceDirect, and Scopus were searched between January 1, 2020, and July 18, 2020, to identify eligible studies. Random-effect models were used to estimate the pooled event rates of pre-existing cardiovascular disease comorbidities and odds ratio (OR) with 95% confidence intervals (95% CIs) of disease severity and mortality associated with the exposures of interest.
A total of 34 studies involving 19,156 patients with COVID-19 infection met the inclusion criteria. The prevalence of pre-existing cardiovascular disease in the included studies was 14.0%. Pre-existing cardiovascular disease in COVID-19 patients was associated with severe outcomes (OR, 4.1; 95% CI, 2.9 to 5.7) and mortality (OR, 6.1; 95% CI, 2.9 to 12.7). Hypertension and coronary heart disease increased the risk of severe outcomes by 2.6 times (OR, 2.6; 95% CI, 1.9 to 3.6) and 2.5 times (OR, 2.5; 95% CI, 1.7 to 3.8), respectively. No significant publication bias was indicated.
COVID-19 patients with pre-existing cardiovascular comorbidities have a higher risk of severe outcomes and mortality. Awareness of pre-existing cardiovascular comorbidity is important for the early management of COVID-19.
本研究旨在评估包括高血压和冠心病在内的既往心血管合并症与2019冠状病毒病（COVID-19）严重程度和死亡率之间的关联。
检索2020年1月1日至2020年7月18日期间的PubMed、ScienceDirect和Scopus数据库，以确定符合条件的研究。采用随机效应模型估计既往心血管疾病合并症的合并事件发生率以及与感兴趣暴露相关的疾病严重程度和死亡率的比值比（OR）及其95%置信区间（95%CI）。
共有34项涉及19156例COVID-19感染患者的研究符合纳入标准。纳入研究中既往心血管疾病的患病率为14.0%。COVID-19患者的既往心血管疾病与严重结局（OR，4.1；95%CI，2.9至5.7）和死亡率（OR，6.1；95%CI，2.9至12.7）相关。高血压和冠心病分别使严重结局的风险增加2.6倍（OR，2.6；95%CI，1.9至3.6）和2.5倍（OR，2.5；95%CI，1.7至3.8）。未显示明显的发表偏倚。
患有既往心血管合并症的COVID-19患者出现严重结局和死亡的风险更高。认识到既往心血管合并症对于COVID-19的早期管理很重要。
