Grantham London B, Kipp Aaron M, Lea C Suzanne, Simeonsson Kristina L
Department of Public Health, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Program on Aging, Chronic Illness, and Long-Term Care, Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
AJPM Focus. 2025 Apr 30;4(4):100359. doi: 10.1016/j.focus.2025.100359. eCollection 2025 Aug.
Individuals with chronic conditions have increased risk of severe COVID-19 infection. Few studies have been conducted in the U.S. regarding their engagement in recommended preventive behaviors. This study examines the associations between chronic conditions and adherence to COVID-19 preventive measures and vaccination intent in a community-based study conducted during the COVID-19 pandemic.
A cross-sectional study was conducted in July-December 2020 among residents in Pitt County, North Carolina. Online surveys collected information on demographics; physical health and health behaviors; and COVID-19 preventive behaviors, including vaccination intent. Logistic regression estimated the associations between any chronic condition (versus none) and adherence to each preventive measure (always/most of the time versus half the time or less), adjusting for age, race, biologic sex, smoking, and alcohol. Analyses were repeated with an increasing number of chronic conditions.
Among 671 participants, adherence to preventive measures was often >90%. Intent to vaccinate showed evidence of a statistically significant dose-response relationship with each additional number of chronic conditions (AOR=1.19; 95% CI=1.03, 1.37). An increased odds of wearing a facemask in public was also found for any chronic condition, although this did not reach statistical significance (AOR=1.69; 95% CI=0.97, 2.95). The authors did not find significant associations between having a chronic condition and adherence to other preventive measures such as avoiding large crowds or distancing 6 feet apart.
Adoption of preventive measures is an essential public health tool during epidemics/pandemics, particularly in the absence of vaccines. The study findings have implications for future public health messaging during a large-scale epidemic based on whether someone is likely engaged with and more trusting of the healthcare system (those with chronic conditions) versus those who are not.
患有慢性病的个体感染重症 COVID-19 的风险增加。在美国,针对他们采取推荐的预防行为的相关研究较少。本研究在 COVID-19 大流行期间开展的一项基于社区的研究中,考察慢性病与 COVID-19 预防措施的依从性以及疫苗接种意愿之间的关联。
2020 年 7 月至 12 月在北卡罗来纳州皮特县的居民中进行了一项横断面研究。通过在线调查收集了人口统计学信息、身体健康和健康行为信息,以及 COVID-19 预防行为信息,包括疫苗接种意愿。逻辑回归分析估计了任何慢性病(与无慢性病相比)与每种预防措施的依从性(总是/大部分时间与一半时间或更少时间)之间的关联,并对年龄、种族、生物性别、吸烟和饮酒情况进行了调整。随着慢性病数量的增加重复进行分析。
在 671 名参与者中,预防措施的依从率通常>90%。疫苗接种意愿显示出与每增加一种慢性病数量存在统计学显著的剂量反应关系(调整后比值比[AOR]=1.19;95%置信区间[CI]=1.03, 1.37)。对于任何慢性病患者,在公共场合佩戴口罩的几率也有所增加,尽管未达到统计学显著性(AOR=1.69;95%CI=0.97, 2.95)。作者未发现患有慢性病与遵守其他预防措施(如避免人群聚集或保持 6 英尺距离)之间存在显著关联。
采取预防措施是疫情/大流行期间至关重要的公共卫生手段,尤其是在没有疫苗的情况下。该研究结果对于未来大规模疫情期间的公共卫生信息传递具有启示意义,具体取决于某人是否可能与医疗保健系统有更多接触且更信任该系统(患有慢性病的人)与那些没有这种情况的人。