Ophthalmology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada
Ophthalmology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
BMJ Case Rep. 2022 Mar 7;15(3):e248441. doi: 10.1136/bcr-2021-248441.
A 14-year-old boy was referred to the ophthalmology department with a 4-day history of rapid-onset right upper lid pain, swelling and erythema starting 9 hours after his first dose of COVID-19 mRNA vaccination (BNT162b2/Comirnaty, Pfizer-BioNTech). On examination, he had significant right upper lid ptosis, oedema and erythema, with associated limitation of right eye abduction and elevation. He was found to have acute dacryoadenitis with orbital inflammatory disease on clinical and laboratory investigations. He was given tapering oral prednisone and had full resolution of symptoms within 2 weeks. This is the first known case of orbital inflammation after COVID-19 mRNA vaccination. Given the temporal association between the patient's vaccination and symptom onset, we believe it is likely that immunisation prompted the onset of disease.
一名 14 岁男孩在接种第一剂 COVID-19 mRNA 疫苗（BNT162b2/Comirnaty，辉瑞-生物科技）后 9 小时出现右上眼睑疼痛、肿胀和红斑，并迅速发展，持续 4 天，随后被转至眼科部门。检查发现，他的右上眼睑明显下垂、水肿和红斑，伴有右眼外展和上抬受限。临床和实验室检查发现他患有急性泪腺炎和眼眶炎症性疾病。他接受了逐渐减量的口服泼尼松治疗，2 周内症状完全缓解。这是已知首例 COVID-19 mRNA 疫苗接种后发生的眼眶炎症病例。鉴于患者接种疫苗和症状出现之间存在时间关联，我们认为免疫接种可能引发了疾病的发生。
