Huizinga W K, Kritzinger N A, Bhamjee A
J Infect. 1986 Jul;13(1):11-6. doi: 10.1016/s0163-4453(86)92118-3.
In a prospective randomised double-blind controlled trial that involved 73 patients with non-invasive wound infections receiving local wound treatment, the effect of adjuvant systemic antibiotic therapy was compared with that of a placebo. On inspection, more wounds were assessed as clinically clean after administration of an antibiotic than after the placebo was given although this difference was not statistically significant. Microbiological evaluation, however, showed a significantly higher cure of sepsis and elimination of individual organisms (P less than 0.05) after antibiotic therapy. Furthermore, eradication of antibiotic-susceptible organisms was significantly greater than that of resistant organisms (P less than 0.005), indicating adequate penetration of antibiotic into the septic wound exudate. The results suggest that appropriate adjuvant systemic antibiotic therapy in the management of infected wounds promotes bacterial clearance and this may enhance healing of wounds.
在一项前瞻性随机双盲对照试验中，73例接受局部伤口治疗的非侵入性伤口感染患者参与其中，将辅助性全身抗生素治疗的效果与安慰剂的效果进行了比较。经检查，使用抗生素后被评估为临床清洁的伤口比使用安慰剂后更多，尽管这种差异无统计学意义。然而，微生物学评估显示，抗生素治疗后败血症的治愈率和个体微生物的清除率显著更高（P<0.05）。此外，对抗生素敏感的微生物的根除率显著高于耐药微生物（P<0.005），表明抗生素能充分渗透到感染伤口渗出物中。结果表明，在感染伤口的处理中，适当的辅助性全身抗生素治疗可促进细菌清除，这可能会加速伤口愈合。
