Brakenbury P H, Muwanga C
Accident and Emergency Department, Middlesbrough General Hospital, England.
Arch Emerg Med. 1989 Dec;6(4):251-6. doi: 10.1136/emj.6.4.251.
The value of prophylactic antibiotics in the treatment of animal bites is uncertain. A prospective double blind stratified trial was performed comparing a broad spectrum antibiotic amoxycillin/clavulanate with placebo in full thickness animal bite wounds in a series of 185 consecutive patients. In wounds less than 9 h old, no significant benefit was found with the antibiotic. In older wounds, presenting 9-24 h after injury, the infection rate was reduced significantly (P = 0.023), although the numbers were small. We recommend the use of such an antibiotic on wounds 9-24 h old and query its use in more recent injuries, unless tendons or joints are likely to be involved.
预防性抗生素在动物咬伤治疗中的价值尚不确定。我们进行了一项前瞻性双盲分层试验，在185例连续的患者中，将广谱抗生素阿莫西林/克拉维酸与安慰剂用于全层动物咬伤伤口进行比较。在伤后9小时内的伤口中，未发现使用抗生素有显著益处。在伤后9 - 24小时出现的较陈旧伤口中，尽管病例数较少，但感染率显著降低（P = 0.023）。我们建议对伤后9 - 24小时的伤口使用此类抗生素，对于更近时间受伤的伤口，除非可能累及肌腱或关节，否则对其使用存疑。
