Ehle A L, Raskin P
J Neurol Sci. 1986 Jul;74(2-3):191-7. doi: 10.1016/0022-510x(86)90104-8.
We studied median, ulnar and peroneal motor nerve conduction velocity (NCV) and median sensory action potential (SAP) latency and amplitude in 18 insulin-dependent diabetic patients who were begun on a continuous subcutaneous insulin infusion (CSII) program. With institution of this therapy, significant decreases in mean blood glucose and glycosylated hemoglobin occurred. After 12 months of CSII treatment, median, peroneal, and ulnar motor NCVs all increased significantly. The average NCV increase was 2.5 m/s. Median SAP amplitude and latency did not significantly change. In a second group of 12 diabetic patients with the same mean age and comparable initial NCV and SAP measures, no significant changes in motor NCVs or SAPs occurred after 12 months of conventional insulin treatment. These results indicated the need for further long-term studies of the role of strict glucose control in the prevention of diabetic neuropathy.
我们研究了18例开始接受持续皮下胰岛素输注（CSII）治疗方案的胰岛素依赖型糖尿病患者的正中神经、尺神经和腓总神经运动神经传导速度（NCV），以及正中神经感觉动作电位（SAP）的潜伏期和波幅。随着该治疗方法的实施，平均血糖和糖化血红蛋白显著下降。CSII治疗12个月后，正中神经、腓总神经和尺神经的运动NCV均显著增加。平均NCV增加了2.5米/秒。正中神经SAP波幅和潜伏期没有显著变化。在第二组12例平均年龄相同、初始NCV和SAP测量值相当的糖尿病患者中，常规胰岛素治疗12个月后，运动NCV或SAP没有显著变化。这些结果表明，需要进一步长期研究严格控制血糖在预防糖尿病神经病变中的作用。
