Dombrowski M P, Savoy-Moore R T, Swartz K, Churchill P C, Mariona F G, Greenwood F C, Bryant-Greenwood G D, Evans M I
J Reprod Med. 1986 Jun;31(6):467-72.
Relaxin decreases human myometrial contractions in vitro; that effect is synergized by progesterone. We examined the effects of porcine relaxin on the contractility of isolated perfused human umbilical arterial strips in vitro. One experimental group received relaxin (1.5 micrograms/mL), the second received progesterone (500 ng/mL) plus relaxin, and the control strips received neither. Both resting and agonist-stimulated (KCl or serotonin) isometric tension were compared with profile analysis for all groups. Relaxin had no effect on either resting or agonist-stimulated tension either with or without progesterone. Neither higher concentrations of relaxin nor longer exposures altered contractility. Therefore, the human umbilical artery, unlike the cervix and myometrium, is not sensitive to porcine relaxin. Porcine relaxin could be used as a tocolytic or cervical ripening agent without adversely affecting fetal placental circulation.
松弛素可在体外降低人子宫肌层的收缩；该作用会被孕酮增强。我们在体外研究了猪松弛素对分离灌注的人脐动脉条收缩性的影响。一个实验组接受松弛素（1.5微克/毫升），第二个实验组接受孕酮（500纳克/毫升）加松弛素，对照组则均不接受。对所有组进行轮廓分析，比较静息和激动剂刺激（氯化钾或5-羟色胺）下的等长张力。无论有无孕酮，松弛素对静息或激动剂刺激的张力均无影响。更高浓度的松弛素或更长时间的暴露均未改变收缩性。因此，与人宫颈和子宫肌层不同，人脐动脉对猪松弛素不敏感。猪松弛素可用作宫缩抑制剂或宫颈成熟剂，而不会对胎儿胎盘循环产生不利影响。
