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股腘旁路血栓静脉移植物的血管肉瘤。

Angiosarcoma of a Femoropopliteal Bypass Thrombosed Vein Graft.

机构信息

Angiology and Vascular Surgery Department, 112085Centro Hospitalar Universitário do Porto, Porto, Portugal.

Kidney Transplant Program, Transplantation Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.

出版信息

Vasc Endovascular Surg. 2022 May;56(4):448-453. doi: 10.1177/15385744221077824. Epub 2022 Mar 8.

DOI:10.1177/15385744221077824
PMID:35258356
Abstract

BACKGROUND

Angiosarcoma is a rare subtype of malignant vascular tumours which has been only anecdotally described in patients submitted to lower limb revascularization.

CASE PRESENTATION

This paper reports a patient previously submitted to a femoropopliteal bypass using autologous great saphenous vein (GSV). Nine years after the initial surgery, a primary angiosarcoma of the thrombosed vein graft was diagnosed, requiring surgical resection. Rampant metastatic spread was documented despite primary tumour surgical resection with a dismal outcome within months.

CONCLUSIONS

Malignant transformation of autologous vein for lower limb revascularization is extremely rare and anecdotally described in the literature. It is a poorly studied complication with an aggressive behaviour. This report further reinforces the need for early recognition of this pathology.

摘要

背景

血管肉瘤是一种罕见的恶性血管肿瘤亚型,仅在接受下肢血运重建的患者中偶有描述。

病例介绍

本文报告了 1 例先前接受自体大隐静脉(GSV)股腘旁路移植术的患者。在初次手术后 9 年,诊断出血栓形成的静脉移植物原发性血管肉瘤,需要手术切除。尽管对原发性肿瘤进行了手术切除,但仍有广泛的转移性播散,数月内预后不佳。

结论

自体静脉用于下肢血运重建的恶性转化极为罕见,在文献中也有描述。这是一种研究甚少但具有侵袭性的并发症。本报告进一步强调了早期识别这种病理的必要性。

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引用本文的文献

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An Update on Implant-Associated Malignancies and Their Biocompatibility.种植体相关性恶性肿瘤及其生物相容性的最新进展
Int J Mol Sci. 2024 Apr 24;25(9):4653. doi: 10.3390/ijms25094653.
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Etiology, pathogenesis, and management of angiosarcoma associated with implants and foreign body: Clinical cases and research updates.与植入物和异物相关的血管肉瘤的病因、发病机制及治疗:临床病例与研究进展
Medicine (Baltimore). 2024 May 3;103(18):e37932. doi: 10.1097/MD.0000000000037932.