Kijlstra A, Van Der Lelij A, Knutson W, Fleuren G J, Vanes L A
Clin Exp Immunol. 1978 May;32(2):207-17.
The blood clearance and hepatic localization of aggregated human IgM (AIgM) were studied in relation to the glomerular localization patterns in rats. AIgM was cleared rapidly from the circulation by sinusoidal cells in the liver, monomeric IgM (MIgM) was cleared less rapidly. Localization of AIgM within the glomerulus was dependent on the level in the blood. Low doses led only to a mesangial localization, whereas high doeses resulted in a localization along the capillary walls. Immunoelectron microscopy showed that in the glomerular capillaries the AIgM was localized within endothelial cells or subendothelially, and did not occur within the glomerular basement membrane. Inhibition of the hepatic uptake of AIgM by colloidal carbon resulted in increased levels of circulating AIgM and prolonged the deposition of AIgM in the glomerular capillaries.
研究了聚集的人IgM（AIgM）的血液清除率和肝定位与大鼠肾小球定位模式的关系。AIgM通过肝脏的窦状细胞从循环中迅速清除，单体IgM（MIgM）清除速度较慢。AIgM在肾小球内的定位取决于血液中的水平。低剂量仅导致系膜定位，而高剂量则导致沿毛细血管壁定位。免疫电子显微镜显示，在肾小球毛细血管中，AIgM定位于内皮细胞内或内皮下，而不在肾小球基底膜内。胶体碳抑制AIgM的肝摄取导致循环中AIgM水平升高，并延长了AIgM在肾小球毛细血管中的沉积。
