Zhu Shaoqun, Pan Yingjie, Sun Yue, Hong Xiaoyan, Chen Xiaoyun, Han Ying, Yan Chaoguo, Shi Yaocheng, Hou Hong
School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212005, China.
J Org Chem. 2022 Mar 18;87(6):4455-4459. doi: 10.1021/acs.joc.1c02949. Epub 2022 Mar 8.
A copper-catalyzed bromo-cyanomethylative cyclization of 1,6-enynes is demonstrated. The treatment of 2-bromoacetonitrile with CuI enables the alkyl radical generation and triggers the radical addition/cyclization/bromination sequence, giving various vinyl C-Br bonds containing functionalized heterocycles in good yields.
已证明1,6-烯炔的铜催化溴氰甲基化环化反应。用碘化亚铜处理2-溴乙腈可产生烷基自由基，并引发自由基加成/环化/溴化序列，以良好的产率得到各种含有官能化杂环的乙烯基C-Br键。
