维生素C与免疫力：证据评估
Vitamin C and immunity: an assessment of the evidence.
作者信息
Thomas W R, Holt P G
出版信息
Clin Exp Immunol. 1978 May;32(2):370-9.
Abstract
The high concentration of ascorbate in leucocytes and its rapid expenditure during infection and phagocytosis suggests a role for the vitamin in the immune process. Evidence published to date shows an involvement in the migration and phagocytosis by macrophages and leucocytes, as well as the induction and expression of delayed hypersensitivity. Its effect on antibody production and complement levels is controversial but probably minimal. This study suggests there is room for further investigation into the effect of ascorbate on immunity, particularly with defined populations, but cautions the use of megadose therapy.
摘要
白细胞中高浓度的抗坏血酸盐及其在感染和吞噬过程中的快速消耗表明该维生素在免疫过程中发挥作用。迄今为止发表的证据显示其参与巨噬细胞和白细胞的迁移与吞噬作用，以及迟发型超敏反应的诱导和表达。其对抗体产生和补体水平的影响存在争议，但可能极小。本研究表明，对于抗坏血酸盐对免疫的影响，尤其是对特定人群的影响，仍有进一步研究的空间，但同时也警示了大剂量疗法的使用。
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