Kataoka Tomoya, Hidaka Junya, Suzuki Jun, Mori Taiki, Nakamura Daigaku, Hotta Yuji, Sanagawa Akimasa, Maeda Yasuhiro, Furukawa-Hibi Yoko, Kimura Kazunori
Department of Clinical Pharmaceutics, Graduate School of Medical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan.
Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan.
Sex Med. 2022 Apr;10(2):100500. doi: 10.1016/j.esxm.2022.100500. Epub 2022 Mar 5.
Carbohydrate restriction in diet is becoming a popular means of losing weight nowadays, although it has been reported that excessive intake of low-carbohydrate and high-protein (LCHP) diet causes an adverse effect on cardiovascular function.
To investigate the influence of LCHP on erectile function in rats.
A total of 48, 12-week-old rats were divided into 2 groups and either fed a LCHP diet (LCHP group) or a normal diet (Control group). Hematological examination, blood pressure evaluation, erectile function assessments as well as evaluations of the relaxation and contractile responses of corpus cavernosum were carried out in these rats by using standardized methods. Statistical analysis using 2-way ANOVA and Welch's t-test was conducted to examine the obtained data.
At the end of the study period, the evaluated outcomes to assess erectile function were intracavernosal pressure , mean arterial pressure , endothelial functions, nitric oxide (NO)-operated nerve functions and the expressions of endothelial nitric oxide synthase (eNOS), neuronal nitric oxide synthase (nNOS), and sphingosine-1-phosphate receptor 1 (S1P1).
The intracavernosal pressure / mean arterial pressure ratio was significantly lower in the LCHP group (P < .05) at 4 weeks. Compared to the Control group, the LCHP group exhibited significantly lower responses to ACh and EFS and a decreased nNOS mRNA expression. The results based on this animal model indicate that extreme carbohydrate restricted diet may affect erectile function. Our study identified that LCHP decreased erectile function in rats. A major limitation of this study is, due to the extreme condition of completely replacing carbohydrates with protein, that carbohydrate intake will be gradually increased in the future.
Extreme carbohydrate restriction and high protein in diet may cause ED with vascular endothelial dysfunction and a decrease in the relaxation response of the corpus cavernosum smooth muscle via NO-operated nerves. Kataoka T, Hidaka J, Suzuki J, et al. Evaluating the Effects of Low Carbohydrate and High Protein Diet on Erectile Function in Rats. Sex Med 2021;10:100500.
饮食中限制碳水化合物如今正成为一种流行的减肥方法，尽管有报道称过量摄入低碳水化合物高蛋白（LCHP）饮食会对心血管功能产生不利影响。
研究LCHP对大鼠勃起功能的影响。
将48只12周龄的大鼠分为2组，分别给予LCHP饮食（LCHP组）或正常饮食（对照组）。采用标准化方法对这些大鼠进行血液学检查、血压评估、勃起功能评估以及海绵体舒张和收缩反应评估。使用双向方差分析和韦尔奇t检验对所得数据进行统计分析。
在研究期结束时，评估勃起功能的指标包括海绵体内压、平均动脉压、内皮功能、一氧化氮（NO）介导的神经功能以及内皮型一氧化氮合酶（eNOS）、神经元型一氧化氮合酶（nNOS）和鞘氨醇-1-磷酸受体1（S1P1）的表达。
4周时，LCHP组的海绵体内压/平均动脉压比值显著降低（P <.05）。与对照组相比，LCHP组对乙酰胆碱（ACh）和电场刺激（EFS）的反应显著降低，且nNOS mRNA表达减少。基于该动物模型的结果表明，极端碳水化合物限制饮食可能会影响勃起功能。我们的研究发现LCHP会降低大鼠的勃起功能。本研究的一个主要局限性在于，由于用蛋白质完全替代碳水化合物的极端条件，未来碳水化合物摄入量将逐渐增加。
饮食中极端碳水化合物限制和高蛋白可能会导致勃起功能障碍，伴有血管内皮功能障碍以及通过NO介导的神经使海绵体平滑肌舒张反应降低。片冈T、日高J、铃木J等。评估低碳水化合物高蛋白饮食对大鼠勃起功能的影响。性医学2021；10：e100500。
