Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,
Central Research Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cerebrovasc Dis. 2022;51(5):655-662. doi: 10.1159/000522439. Epub 2022 Mar 8.
Although inflammation is found to be related to arteriopathy pathogenesis, it is yet to be determined the distinct correlations of specific inflammatory biomarker types contributing to different cerebral large vessel diseases. We aimed to investigate the association between multiple inflammatory biomarkers and cerebral atherosclerosis and dolichoectasia in a community-based sample.
A total of 960 participants of the Shunyi study were included. A panel of 14 circulatory inflammatory biomarkers was assessed and then grouped in three sets as systemic, endothelial-related, and media-related inflammation, based on underlying different inflammatory cascades. Intracranial atherosclerotic stenosis (ICAS), dolichoectasia estimated by magnetic resonance angiography, and carotid plaques estimated by ultrasound were also performed.
Endothelial-related inflammatory group was related to the presence of ICAS (R2 = 0.215, p = 0.024) and carotid plaques (R2 = 0.342, p = 0.013). Backward stepwise elimination showed that E-selectin was prominent (β = 0.67, 95% CI: 0.54-0.85, p = 0.001; β = 0.79, 95% CI: 0.68-0.93, p = 0.005). Systemic inflammatory group was associated with an increased basilar artery diameter (R2 = 0.051, p < 0.001), and backward stepwise elimination showed that IL-6 was prominent (β = 0.07, 95% CI: 0.03-0.11, p < 0.001).
Different types of inflammatory biomarkers were associated with atherosclerosis and dolichoectasia, respectively, implying dissimilar inflammatory processes. Further confirming of their distinct anti-inflammatory roles as potential therapeutic targets is warrant.
尽管炎症与动脉病变的发病机制有关，但仍需确定特定炎症生物标志物类型与不同脑大血管疾病的具体相关性。我们旨在调查在社区人群中，多种炎症生物标志物与脑动脉粥样硬化和长段梭形扩张的关系。
本研究共纳入了顺义研究中的 960 名参与者。评估了 14 种循环炎症生物标志物，并根据不同的炎症级联反应将其分为三组，即系统性、内皮相关和中膜相关炎症。还进行了颅内动脉粥样硬化狭窄（ICAS）、磁共振血管造影估计的长段梭形扩张和超声估计的颈动脉斑块的评估。
内皮相关炎症组与 ICAS（R2 = 0.215，p = 0.024）和颈动脉斑块（R2 = 0.342，p = 0.013）的存在相关。逐步向后消除显示 E-选择素较为突出（β = 0.67，95%CI：0.54-0.85，p = 0.001；β = 0.79，95%CI：0.68-0.93，p = 0.005）。系统性炎症组与基底动脉直径增加相关（R2 = 0.051，p < 0.001），逐步向后消除显示 IL-6 较为突出（β = 0.07，95%CI：0.03-0.11，p < 0.001）。
不同类型的炎症生物标志物分别与动脉粥样硬化和长段梭形扩张相关，提示存在不同的炎症过程。进一步证实它们作为潜在治疗靶点的不同抗炎作用是必要的。
