用于传感的近红外（NIR）发射荧光探针的设计与开发及其生物成像应用的最新进展。

Recent Advancements in the Design and Development of Near Infrared (NIR) Emitting Fluorescent Probes for Sensing and their Bio-Imaging Applications.

作者信息

Vijay Natarajan, Magesh Kuppan, M Renny Louis, Velmathi Sivan

机构信息

Organic and Polymer Synthesis Laboratory, Department of Chemistry, National Institute of Technology, Tiruchirappalli - 620 015, India.

出版信息

Curr Org Synth. 2023;20(1):114-175. doi: 10.2174/1570179419666220308145901.

DOI:10.2174/1570179419666220308145901

PMID:35260055

Abstract

Fluorescent bio-imaging will be the future in the medical diagnostic for visualising inner cellular and tissues. Near-infrared (NIR) emitting fluorescent probes serve dynamically for targeted fluorescent imaging of live cells and tissues. NIR imaging is advantageous because of its merits like deep tissue penetration, minimum damage to the tissue, reduced auto fluorescence from the background, and improved resolution in imaging. The Development of the NIR emitting probe was well explored recently and growing drastically. In this review, we summarise recent achievements in NIR probes in between 2018-2021. The merits and future applications have also been discussed in this review.

摘要

荧光生物成像将成为可视化细胞内部和组织的医学诊断的未来方向。发射近红外（NIR）的荧光探针可动态用于活细胞和组织的靶向荧光成像。近红外成像具有优势，因为它具有诸如深层组织穿透、对组织的损伤最小、背景自发荧光减少以及成像分辨率提高等优点。最近对发射近红外探针的开发进行了充分探索，并且正在急剧发展。在本综述中，我们总结了2018年至2021年间近红外探针的最新成果。本综述还讨论了其优点和未来应用。