用于金属离子的 TP/NIR 荧光探针的最新进展。
Recent progress of TP/NIR fluorescent probes for metal ions.
机构信息
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, South Korea; New and Renewable Energy Research Center, Ewha Womans University, Seoul, 03760, South Korea.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, 211816, China.
出版信息
Curr Opin Chem Biol. 2023 Aug;75:102321. doi: 10.1016/j.cbpa.2023.102321. Epub 2023 May 15.
Metal ions are of significance in various pathological and physiological processes. As such, it is crucial to monitor their levels in organisms. Two-photon (TP) and near-infrared (NIR) fluorescence imaging has been utilized to monitor metal ions because of minimal background interference, deeper tissue depth penetration, lower tissue self-absorption, and reduced photodamage. In this review, we briefly summarize recent progress from 2020 to 2022 of TP/NIR organic fluorescent probes and inorganic sensors in the detection of metal ions. Additionally, we present an outlook for the development of TP/NIR probes for bio-imaging, diagnosis of diseases, imaging-guided therapy, and activatable phototherapy.
金属离子在各种病理和生理过程中都具有重要意义。因此，监测生物体中金属离子的水平至关重要。双光子（TP）和近红外（NIR）荧光成像是监测金属离子的常用方法，因为其背景干扰最小、组织深度穿透更深、组织自吸收更低且光损伤更小。在本文中，我们简要总结了 2020 年至 2022 年期间，用于检测金属离子的 TP/NIR 有机荧光探针和无机传感器的最新进展。此外，我们还展望了用于生物成像、疾病诊断、成像引导治疗和可激活光疗的 TP/NIR 探针的发展。
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