Wan Ben, Wang Renxian, Sun Yuyang, Cao Jingjing, Wang Honggang, Guo Jianxun, Chen Dafu
Laboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing, China.
Front Bioeng Biotechnol. 2020 Oct 7;8:591467. doi: 10.3389/fbioe.2020.591467. eCollection 2020.
Bioceramics have experienced great development over the past 50 years. Modern bioceramics are designed to integrate bioactive ions within ceramic granules to trigger living tissue regeneration. Preclinical and clinical studies have shown that strontium is a safe and effective divalent metal ion for preventing osteoporosis, which has led to its incorporation in calcium phosphate-based ceramics. The local release of strontium ions during degradation results in moderate concentrations that trigger osteogenesis with few systemic side effects. Moreover, strontium has been proven to generate a favorable immune environment and promote early angiogenesis at the implantation site. Herein, the important aspects of strontium-enriched calcium phosphate bioceramics (Sr-CaPs), and how Sr-CaPs affect the osteogenic microenvironment, are described.
在过去50年里，生物陶瓷经历了巨大的发展。现代生物陶瓷的设计目的是将生物活性离子整合到陶瓷颗粒中，以触发活组织再生。临床前和临床研究表明，锶是一种预防骨质疏松症的安全有效的二价金属离子，这促使其被纳入磷酸钙基陶瓷中。降解过程中锶离子的局部释放会产生适度的浓度，从而触发骨生成，且几乎没有全身副作用。此外，锶已被证明能产生有利的免疫环境，并促进植入部位的早期血管生成。在此，描述了富锶磷酸钙生物陶瓷（Sr-CaPs）的重要方面，以及Sr-CaPs如何影响成骨微环境。
