Department of Pathology, State University of New York at Buffalo, Buffalo, New York, USA
Department of Otolaryngology - Head and Neck Surgery, State University of New York at Buffalo, Buffalo, New York, USA.
BMJ Case Rep. 2022 Mar 8;15(3):e247932. doi: 10.1136/bcr-2021-247932.
Squamous cell carcinoma (SCC) is uncommon in African Americans (AAs), with an incidence of approximately 0.003%. However, it is the most common skin cancer in that patient population. In AAs, SCC typically arises in sun-protected areas and mainly affects patients older than 50 years. We report a case of giant SCC in an AA man in his 40s with long-standing folliculitis decalvans on the scalp. Three previous skin biopsies were inconclusive. A wide excision was performed and the defect was reconstructed with an anterolateral thigh free flap. Histological analysis of the resected specimen revealed a well-moderately differentiated keratinising SCC with clear cell changes, severe mixed inflammation, folliculitis and dermal scar. He was discharged 2 weeks later and has been followed up closely. Four months later, the patient presents with metastatic SCC to an occipital lymph node.
鳞状细胞癌（SCC）在非裔美国人（AA）中较为罕见，发病率约为 0.003%。然而，它是该患者群体中最常见的皮肤癌。在 AA 中，SCC 通常发生在防晒区域，主要影响 50 岁以上的患者。我们报告了一例 40 多岁的 AA 男性的巨大 SCC 病例，该患者头皮上有长期的脱发性毛囊炎。此前进行了三次皮肤活检，但结果均不明确。我们进行了广泛切除，并使用股前外侧游离皮瓣进行了缺损重建。切除标本的组织学分析显示为分化良好至中度的角化 SCC，伴有透明细胞改变、严重混合性炎症、毛囊炎和真皮瘢痕。两周后患者出院，此后进行了密切随访。四个月后，患者出现 SCC 向枕部淋巴结转移。
