头皮巨大鳞状细胞癌，发生于匐行性脱发性毛囊炎背景下。
Giant cutaneous squamous cell carcinoma of the scalp arising in the setting of folliculitis decalvans.
机构信息
Department of Pathology, State University of New York at Buffalo, Buffalo, New York, USA
Department of Otolaryngology - Head and Neck Surgery, State University of New York at Buffalo, Buffalo, New York, USA.
出版信息
BMJ Case Rep. 2022 Mar 8;15(3):e247932. doi: 10.1136/bcr-2021-247932.
Squamous cell carcinoma (SCC) is uncommon in African Americans (AAs), with an incidence of approximately 0.003%. However, it is the most common skin cancer in that patient population. In AAs, SCC typically arises in sun-protected areas and mainly affects patients older than 50 years. We report a case of giant SCC in an AA man in his 40s with long-standing folliculitis decalvans on the scalp. Three previous skin biopsies were inconclusive. A wide excision was performed and the defect was reconstructed with an anterolateral thigh free flap. Histological analysis of the resected specimen revealed a well-moderately differentiated keratinising SCC with clear cell changes, severe mixed inflammation, folliculitis and dermal scar. He was discharged 2 weeks later and has been followed up closely. Four months later, the patient presents with metastatic SCC to an occipital lymph node.
鳞状细胞癌（SCC）在非裔美国人（AA）中较为罕见，发病率约为 0.003%。然而，它是该患者群体中最常见的皮肤癌。在 AA 中，SCC 通常发生在防晒区域，主要影响 50 岁以上的患者。我们报告了一例 40 多岁的 AA 男性的巨大 SCC 病例，该患者头皮上有长期的脱发性毛囊炎。此前进行了三次皮肤活检，但结果均不明确。我们进行了广泛切除，并使用股前外侧游离皮瓣进行了缺损重建。切除标本的组织学分析显示为分化良好至中度的角化 SCC，伴有透明细胞改变、严重混合性炎症、毛囊炎和真皮瘢痕。两周后患者出院，此后进行了密切随访。四个月后，患者出现 SCC 向枕部淋巴结转移。
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