Henson V, Maclaren N, Winter W, Riley W, Rotter J, Wakeland E K
Mol Biol Med. 1986 Apr;3(2):129-36.
Insulin-dependent diabetes mellitus is an autoimmune disease the development of which is influenced by genetic factors (Cahill & McDevitt, 1981). As concordance for IDD is less than 50% in identical twins, environmental factors are also required for the development of IDD. Although viral agents have been implicated in the past, the specific environmental components leading to IDD remain unknown. This paper reviews current research focused on the genetic factors that influence susceptibility to IDD.
胰岛素依赖型糖尿病是一种自身免疫性疾病，其发病受遗传因素影响（卡希尔和麦克德维特，1981年）。由于同卵双胞胎中胰岛素依赖型糖尿病的一致性低于50%，因此胰岛素依赖型糖尿病的发病也需要环境因素。尽管过去曾认为病毒因素与之有关，但导致胰岛素依赖型糖尿病的具体环境因素仍不清楚。本文综述了目前针对影响胰岛素依赖型糖尿病易感性的遗传因素的研究。
