Ayre S G, Perez Garcia y Bellon D, Perez Garcia D
Med Hypotheses. 1986 Jun;20(2):199-210. doi: 10.1016/0306-9877(86)90126-x.
In insulin potentiation therapy the hormone insulin is used as an adjunct in the medical management of the chronic degenerative diseases including malignant neoplasia. In this, the recognized physiological action of insulin--that of increasing cell membrane permeability--is taken advantage of to potentiate the pharmacological actions of medications administered concurrently in the therapy. This potentiation occurs because of the heretofore unrecognized applicability of this membrane permeabilizing effect of insulin to a much wider range of tissues than is classicly accepted, and further the observed effect of this permeabilizing phenomenon as it relates to drug molecules, most importantly the antineoplastic agents. The historical context of insulin potentiation therapy is described, and scientific corroboration for its novel hypotheses is given. Insulin potentiation therapy represents a potentially revolutionary concept in the medical management of diseases and is, in the authors' opinion, deserving of intensive scientific investigation through in vitro and in vivo experimentation and properly conducted human clinical trials in a university teaching hospital setting.
在胰岛素增强疗法中，激素胰岛素被用作包括恶性肿瘤在内的慢性退行性疾病药物治疗的辅助手段。在此疗法中，人们利用胰岛素公认的生理作用——增加细胞膜通透性，来增强治疗中同时使用的药物的药理作用。这种增强作用的发生是因为胰岛素的这种膜通透作用迄今未被认识到的更广泛适用性，超出了传统认知范围，此外还因为观察到这种通透现象与药物分子（最重要的是抗肿瘤药物）的关系。文中描述了胰岛素增强疗法的历史背景，并对其新假说提供了科学佐证。胰岛素增强疗法代表了疾病药物治疗中一个潜在的革命性概念，在作者看来，值得通过体外和体内实验以及在大学教学医院环境中妥善开展的人体临床试验进行深入科学研究。
