Horowitz S H
Muscle Nerve. 1986 Jul-Aug;9(6):531-6. doi: 10.1002/mus.880090609.
Cronassial, a combination of four different cerebral gangliosides, was administered intramuscularly (40 mg daily) in a double-blind controlled study of 28 patients with moderate to severe diabetic neuropathy. Clinical neurologic and near-nerve electrophysiologic studies were performed. The 14 patients receiving gangliosides experienced statistically significant improvement in their clinical scores due to an increase in lower extremity sensory perception. No other clinical or electrophysiologic changes were present. No side effects were noted. Further studies employing greater numbers of patients and higher doses are required to confirm the efficacy of gangliosides in diabetic neuropathy.
克腊纳西亚（Cronassial）是四种不同脑苷脂的组合，在一项针对28例中重度糖尿病性神经病变患者的双盲对照研究中，采用肌肉注射给药（每日40毫克）。进行了临床神经学和近神经电生理学研究。接受神经节苷脂治疗的14例患者由于下肢感觉知觉增强，临床评分有统计学意义的显著改善。未出现其他临床或电生理变化。未观察到副作用。需要采用更多患者和更高剂量进行进一步研究，以证实神经节苷脂对糖尿病性神经病变的疗效。
