Liu Huihui, Zhang Zhengyang, Song Lian, Gao Jie, Liu Yanfang
Department of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
Oncol Lett. 2022 Apr;23(4):119. doi: 10.3892/ol.2022.13239. Epub 2022 Feb 9.
Cancer stem cells (CSCs), also termed cancer-initiating cells, are a special subset of cells with high self-replicating and self-renewing abilities that can differentiate into various cell types under certain conditions. A number of studies have demonstrated that CSCs have distinct metabolic properties. The reprogramming of energy metabolism enables CSCs to meet the needs of self-renewal and stemness maintenance. Increasing evidence supports the view that alterations in lipid metabolism, including an increase in fatty acid (FA) uptake, lipogenesis, formation of lipid droplets and mitochondrial FA oxidation, are involved in CSC regulation. In the present review, the metabolic characteristics of CSCs, particularly in lipid metabolism, were summarized. In addition, the potential mechanisms of CSC lipid metabolism in treatment resistance were discussed. Given their significance in cancer biology, targeting CSC metabolism may serve an important role in future cancer treatment.
癌症干细胞（CSCs），也被称为癌症起始细胞，是具有高自我复制和自我更新能力的特殊细胞亚群，在特定条件下可分化为各种细胞类型。大量研究表明，癌症干细胞具有独特的代谢特性。能量代谢重编程使癌症干细胞能够满足自我更新和维持干性的需求。越来越多的证据支持这样一种观点，即脂质代谢的改变，包括脂肪酸（FA）摄取增加、脂肪生成、脂滴形成和线粒体脂肪酸氧化，都参与了癌症干细胞的调控。在本综述中，总结了癌症干细胞的代谢特征，特别是脂质代谢方面的特征。此外，还讨论了癌症干细胞脂质代谢在治疗耐药性中的潜在机制。鉴于它们在癌症生物学中的重要性，靶向癌症干细胞代谢可能在未来癌症治疗中发挥重要作用。
