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口腔扁平苔藓病损中感染的影响

The Implication of Infection in Oral Lichen Planus Lesions.

作者信息

Parlatescu Ioanina, Nicolae Carmen, Tovaru Serban, Radu Lavinia, Penes Ovidiu, Varlas Valentin

机构信息

Oral Medicine Department, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

出版信息

Maedica (Bucur). 2021 Dec;16(4):585-589. doi: 10.26574/maedica.2021.16.4.585.

Abstract

The purpose of this study is to determine if superimposed infection with Candida species in oral lichen planus exacerbates the clinical symptoms and lesions. We conducted a retrospective study on the medical charts of oral lichen planus (OLP) patients diagnosed by clinical and histopathological criteria. A baseline demographic, anamnestic, clinical data, results of the oral candida investigations were analyzed and recorded for all patients. From a total number of 203 OLP patients, oral candidiasis was diagnosed in 75 (36.94%) cases. There was no statistical significance between the clinical forms of lichen planus and the presence of Candida infection. Of all encountered Candida species, Candida albicans was most commonly detected, followed by Candida krusei, Candida lusitaniae, and Candida tropicalis. Although our study is limited regarding the sample size and no statistically significant difference has been found between clinical features of OLP and oral candidiasis, a routine screening of OLP patients for oral candidiasis and a preventive antifungal strategy in the OLP treatment schedule is needed.

摘要

本研究的目的是确定口腔扁平苔藓患者合并念珠菌属感染是否会加重临床症状和病损。我们对根据临床和组织病理学标准诊断为口腔扁平苔藓(OLP)的患者病历进行了回顾性研究。分析并记录了所有患者的基线人口统计学、既往史、临床数据以及口腔念珠菌检查结果。在总共203例OLP患者中,75例(36.94%)诊断为口腔念珠菌病。扁平苔藓的临床类型与念珠菌感染的存在之间无统计学意义。在所有检出的念珠菌属中,白色念珠菌最常被检测到,其次是克柔念珠菌、葡萄牙念珠菌和热带念珠菌。尽管我们的研究在样本量方面存在局限性,且未发现OLP的临床特征与口腔念珠菌病之间有统计学显著差异,但仍需要对OLP患者进行口腔念珠菌病的常规筛查,并在OLP治疗方案中采取预防性抗真菌策略。

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