脓毒症和新冠肺炎中的白蛋白动力学
Albumin Kinetics in Sepsis and COVID-19.
作者信息
Siddiqui Suhail Sarwar, Chakraborty Nilanchal, Muzaffar Syed Nabeel, Gurjar Mohan
机构信息
Department of Critical Care Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
Institute of Neuroscience, Kolkata, India.
出版信息
Crit Care Explor. 2022 Mar 1;4(3):e0651. doi: 10.1097/CCE.0000000000000651. eCollection 2022 Mar.
Abstract
Hypoalbuminemia has been associated with poor outcome in critically ill population including sepsis and COVID-19. The observational study by Su et al showed a favorable albumin kinetics, with an initial downwards trend followed by recovery back to the predicted albumin levels, in survivors of COVID-19 and sepsis-induced acute respiratory distress syndrome (ARDS). However, nonsurvivors in COVID-19 group did not have an upwards recovery slope, while those in sepsis group did not follow any sort of albumin kinetics. Thus, authors concluded that the pattern of albumin kinetics may be predictive of outcome in COVID-19 and sepsis-induced ARDS. Here, we would like to highlight a few more points in this letter.
摘要
低白蛋白血症与包括脓毒症和新冠肺炎在内的危重症人群的不良预后相关。Su等人的观察性研究表明，在新冠肺炎和脓毒症诱发的急性呼吸窘迫综合征（ARDS）幸存者中，白蛋白动力学良好，最初呈下降趋势，随后恢复到预测的白蛋白水平。然而，新冠肺炎组的非幸存者没有向上的恢复斜率，而脓毒症组的患者则没有遵循任何白蛋白动力学模式。因此，作者得出结论，白蛋白动力学模式可能预测新冠肺炎和脓毒症诱发的ARDS的预后。在此，我们想在这封信中再强调几点。
相似文献
1
Albumin Kinetics in Sepsis and COVID-19.脓毒症和新冠肺炎中的白蛋白动力学
Crit Care Explor. 2022 Mar 1;4(3):e0651. doi: 10.1097/CCE.0000000000000651. eCollection 2022 Mar.
2
Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome.与脓毒症诱导的急性呼吸窘迫综合征患者相比，2019冠状病毒病重症患者白蛋白动力学的评估
Crit Care Explor. 2021 Dec 2;3(12):e0589. doi: 10.1097/CCE.0000000000000589. eCollection 2021 Dec.
3
Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series.围生期组织来源的间充质干细胞治疗危重症 COVID-19 诱导的 ARDS 患者：病例系列。
Stem Cell Res Ther. 2021 Jan 29;12(1):91. doi: 10.1186/s13287-021-02165-4.
4
Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis.严重 COVID-19 患者血浆中的细胞因子谱与 ARDS 和脓毒症无差异。
JCI Insight. 2020 Sep 3;5(17):140289. doi: 10.1172/jci.insight.140289.
5
Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome.急性呼吸窘迫综合征的危重症 COVID-19 患者中 IFN-I 活性和免疫特征的纵向评估。
Crit Care. 2021 Apr 12;25(1):140. doi: 10.1186/s13054-021-03558-w.
6
Hypoalbuminemia on admission in COVID-19 infection: An early predictor of mortality and adverse events. A retrospective observational study.COVID-19 感染入院时的低白蛋白血症：死亡和不良事件的早期预测指标。一项回顾性观察研究。
Med Clin (Barc). 2021 May 7;156(9):428-436. doi: 10.1016/j.medcli.2020.12.018. Epub 2021 Jan 28.
7
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.拯救脓毒症运动：严重脓毒症和脓毒性休克管理国际指南：2012 年。
Crit Care Med. 2013 Feb;41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af.
8
Serum MMP-8 and TIMP-1 in critically ill patients with acute respiratory failure: TIMP-1 is associated with increased 90-day mortality.危重症急性呼吸衰竭患者血清 MMP-8 和 TIMP-1：TIMP-1 与 90 天死亡率升高相关。
Anesth Analg. 2014 Apr;118(4):790-8. doi: 10.1213/ANE.0000000000000120.
9
Albumin and fibrinogen kinetics in sepsis: a prospective observational study.脓毒症中的白蛋白和纤维蛋白原动力学：一项前瞻性观察研究。
Crit Care. 2021 Dec 17;25(1):436. doi: 10.1186/s13054-021-03860-7.
10
Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome.急性呼吸窘迫综合征患者支气管肺泡灌洗中的炎性细胞因子。随时间持续升高预示预后不良。
Chest. 1995 Nov;108(5):1303-14. doi: 10.1378/chest.108.5.1303.
引用本文的文献
1
Hypoalbuminemia is Highly Prevalent in Patients with Periprosthetic Joint Infection and Strongly Associated with Treatment Failure.低蛋白血症在假体周围关节感染患者中非常普遍，并且与治疗失败密切相关。
Orthop Surg. 2024 Oct;16(10):2419-2427. doi: 10.1111/os.14162. Epub 2024 Jul 25.
2
Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review).入住重症监护病房的COVID-19危重症患者实验室检查特征的时间演变（综述）
Med Int (Lond). 2023 Sep 14;3(5):52. doi: 10.3892/mi.2023.112. eCollection 2023 Sep-Oct.
3
Serum biomarkers for nutritional status as predictors in COVID-19 patients before and after vaccination.作为预测指标的营养状况血清生物标志物在COVID-19患者疫苗接种前后的情况。
J Funct Foods. 2023 Feb;101:105412. doi: 10.1016/j.jff.2023.105412. Epub 2023 Jan 10.
4
COVID-19: critical case of a patient with an atypical manifestation of the disease.COVID-19：一例疾病非典型表现的重症患者。
Diagn Pathol. 2023 Jan 12;18(1):4. doi: 10.1186/s13000-023-01289-w.
5
The relationship between hematocrit and serum albumin levels difference and mortality in elderly sepsis patients in intensive care units-a retrospective study based on two large database.基于两个大型数据库的回顾性研究：老年脓毒症患者 ICU 中血细胞比容和血清白蛋白水平差值与死亡率的关系。
BMC Infect Dis. 2022 Jul 18;22(1):629. doi: 10.1186/s12879-022-07609-7.
本文引用的文献
1
Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome.与脓毒症诱导的急性呼吸窘迫综合征患者相比，2019冠状病毒病重症患者白蛋白动力学的评估
Crit Care Explor. 2021 Dec 2;3(12):e0589. doi: 10.1097/CCE.0000000000000589. eCollection 2021 Dec.
2
Interstitial washdown and vascular albumin refill during fluid infusion: novel kinetic analysis from three clinical trials.输液过程中的组织间液冲洗和血管内白蛋白再填充：来自三项临床试验的新型动力学分析
Intensive Care Med Exp. 2021 Aug 27;9(1):44. doi: 10.1186/s40635-021-00407-6.
3
Hypoalbuminemia on admission in COVID-19 infection: An early predictor of mortality and adverse events. A retrospective observational study.COVID-19感染入院时的低白蛋白血症：死亡率和不良事件的早期预测指标。一项回顾性观察研究。
Med Clin (Engl Ed). 2021 May 7;156(9):428-436. doi: 10.1016/j.medcle.2020.12.015. Epub 2021 May 1.
4
COVID 19: in the eye of the cytokine storm.新冠病毒 19：处于细胞因子风暴之中
Eur Heart J. 2021 Jan 7;42(2):150-151. doi: 10.1093/eurheartj/ehaa1005.
5
Hypoalbuminemia: Pathogenesis and Clinical Significance.低蛋白血症：发病机制与临床意义。
JPEN J Parenter Enteral Nutr. 2019 Feb;43(2):181-193. doi: 10.1002/jpen.1451. Epub 2018 Oct 4.
6
Hypoalbuminemia and Clinical Outcomes: What is the Mechanism behind the Relationship?低蛋白血症与临床结局：两者关系背后的机制是什么？
Am Surg. 2017 Nov 1;83(11):1220-1227. doi: 10.1177/000313481708301123.
7
Albumin Kinetics in Patients Undergoing Major Abdominal Surgery.接受腹部大手术患者的白蛋白动力学
PLoS One. 2015 Aug 27;10(8):e0136371. doi: 10.1371/journal.pone.0136371. eCollection 2015.
8
The C-Reactive Protein/Albumin Ratio as an Independent Predictor of Mortality in Patients with Severe Sepsis or Septic Shock Treated with Early Goal-Directed Therapy.C反应蛋白/白蛋白比值作为早期目标导向治疗的严重脓毒症或脓毒性休克患者死亡率的独立预测指标
PLoS One. 2015 Jul 9;10(7):e0132109. doi: 10.1371/journal.pone.0132109. eCollection 2015.
Zotero 插件